Human genetics is undergoing an information explosion. The availability of chip-based technology facilitates the measurement of thousands of DNA sequence variation from across the human genome. The challenge is to sift through these high-dimensional datasets to identify combinations of interacting DNA sequence variations that are predictive of common diseases. The goal of this paper was to deve...

This paper proposes a heuristic method based on ant colony optimization to determine the suboptimal allocation of dynamic multi-attribute dispatching rules to maximize job shop system performance (four measures were analyzed: mean flow time, max flow time, mean tardiness, and max tardiness). In order to assure high adequacy of the job shop system representation, modeling is carried out using di...

We present a specific varying fitness function technique in genetic algorithm (GA) constrained optimization. This technique incorporates the problem's constraints into the fitness function in a dynamic way. It consists of forming a fitness function with varying penalty terms. The resulting varying fitness function facilitates the GA search. The performance of the technique is tested on two opti...

This paper evaluates the usage of analytical programming and different fitness functions for software effort estimation. Analytical programming and differential evolution generate regression functions. These functions are evaluated by the fitness function which is part of differential evolution. The differential evolution requires a proper fitness function for effective optimization. The proble...

* Correspondence author. Abstract The fuzzy multi-attribute decision making problems are investigated, in which the attribute values are given as intervalvalued intuitionistic fuzzy numbers and the attribute weight information is incomplete. Some operational laws of interval-valued intuitionistic fuzzy numbers, score function and accuracy function of interval-valued intuitionistic fuzzy numbers...

Aging is associated with the functional decline of cells, tissues, and organs. At the same time, age is the single most important prognostic factor in the development of most human cancers, including chronic myelogenous and acute lymphoblastic leukemias initiated by Bcr-Abl oncogenic translocations. Prevailing paradigms attribute the association between aging and cancers to the accumulation of ...

Surrogate models of fitness have been presented as a way of reducing the number of fitness evaluations required by evolutionary algorithms. This is of particular interest with expensive fitness functions where the time taken for building the model is outweighed by the saving of using fewer function evaluations. In this paper, we show how a Markov network model can be used as a surrogate fitness...

In a recent paper [Phys. Rev. E 69, 046121 (2004)]], we used the Suzuki-Trottere formalism to study a quasispecies biological evolution model in a parallel mutation-selection scheme with a single-peak fitness function and a point mutation. In the present paper, we extend such a study to evolution models with more general fitness functions or multiple mutations in the parallel mutation-selection...

The probabilistic concept formation general problem in dealing with mixed-data scale environments is due to the use of different evaluation function for each attribute type. We claim that different behaviors for discrete and continuous evaluation functions are due to an unbalanced contribution for each attribute-type evaluation function inside the main evaluation function. This paper describes ...

BACKGROUND This paper is the second of two reports that together review the scientific evidence regarding the inverse relation between physical activity and cardiovascular fitness and coronary heart disease (CHD). METHODS Using a MEDLINE search with the key words exercise, physical fitness, coronary heart disease, and cardiovascular disease, more than 75 articles were reviewed, evaluating stu...