This article has summarized observations and results of controlled laboratory and clinical studies of drug-induced gingival hyperplasia associated with phenytoin, cyclosporine, and nifedipine use. Furthermore, information regarding the pharmacologic aspects of these medications is presented. More information is needed for a greater understanding of drug-induced gingival hyperplasia. It appears ...

Oral tissues show different response and behavior to different oral diseases and treatment procedures. A clinically healthy periodontium has shown to have a varied phenotypic appearance differing from subject to subject. Several researchers, onlookers, academicians, and clinicians have tried to study in their ways about these different gingival entities. Apart from, various local factors, host ...

BACKGROUND/PURPOSE Lysine-specific gingipain (Kgp) is a virulence factor secreted from Porphyromonas gingivalis (P. gingivalis), a major etiological bacterium of periodontal disease. Keratin intermediate filaments maintain the structural integrity of gingival epithelial cells, but are targeted by Kgp to produce a novel cytokeratin 6 fragment (K6F). We investigated the release of K6F and its ind...

Gingival overgrowth is an undesirable outcome of systemic medication and is evidenced by the accretion of collagenous components in gingival connective tissues along with diverse degrees of inflammation. Phenytoin therapy has been found to induce the most fibrotic lesions in gingiva, cyclosporine caused the least fibrotic lesions, and nifedipine induced intermediate fibrosis in drug‑induced gin...

PURPOSE The concept of gingival biotype has been used as a predictor of periodontal therapy outcomes since the 1980s. In the present study, prospective and controlled experiments were performed to compare periodontal pocket depth (PPD) reduction and gingival shrinkage (GSH) after scaling and root planing (SRP) according to gingival biotype. METHODS Twenty-five patients diagnosed with chronic ...

BACKGROUND Gingival hyperplasia is a known complication of cyclosporin therapy. Although plaque control has been shown to be of benefit, gingival surgery is occasionally necessary. The aim of this study was to review the effect of a short-course therapy with azithromycin in renal transplant patients with cyclosporin-induced gingival hyperplasia. METHODS Thirty-eight patients received 500 mg/d...

Background: Gingival recession (GR) is one of the most common esthetic problems affecting middle and older aged peoples. GR can lead to many changes as root caries, hypersensitivity, erosions, abrasions, plaque retention aesthetic dissatisfaction. This study aimed evaluate prevalence gingival in relation mucogingival deformities lower zone. Methods: A cross-sectional was done on a sample 290 fe...

AIM This article describes the surgical management of a young, female patient with severe gingival enlargement of unknown etiology. BACKGROUND Gingival enlargement frequently occurs as gingival hyperplasia, representing a reaction to a known stimulus or agent and, histopathologically, implies an increase in both extracellular matrix and cell numbers. The enlargement may range from mild, in wh...

The width of the attached gingiva of 54 children 12-14 years old was measured and compared with its width measured five years before. The width of the attached gingiva of 96 mandibular permanent central incisors at the second examination was grouped according to its width at the first examination. In addition, the width of the attached gingiva of 67 mandibular central incisors, at both examinat...

Gingival recession is characterized by the apical migration of the gingival margin, exposing the root surface. Studies have demonstrated several etiological factors for gingival recession such as periodontitis, traumatic toothbrushing, use of oral piercing, and past orthodontic therapy, among others. It might not be possible to identify and quantify the influence of each factor, and gingival re...