The application of biomarkers in medicine is evolving. Biomarkers do not only give us a better understanding of pathogenesis, but also increase treatment efficacy and safety, further enabling more precise clinical care. This paper focuses on the current use of biomarkers in atopic dermatitis, new developments and future perspectives. Biomarkers can be used for many different purposes, including...

BACKGROUND Two steroid-free, over-the-counter skin protectant products have been developed for the care and treatment of atopic dermatitis (AD)-Eucerin Eczema Relief Body Crème (Body Cream) for daily skin moisturization and Eucerin Eczema Relief Instant Therapy cream (Instant Therapy) for treatment of AD flare-ups. We tested the efficacy and tolerability of these formulations in infants and chi...

Atopic dermatitis (AD) is a common disease in childhood and an important risk factor for the later development of other atopic diseases. Many publications on childhood AD use questionnaires based on information obtained in adulthood, which introduce the possibility of recall bias. In a prospective cohort study, recall bias was evaluated in 1,501 unselected schoolchildren (mean age 14 years) eva...

BACKGROUND Oligosaccharides may alter postnatal immune development by influencing the constitution of gastrointestinal bacterial flora. AIMS To investigate the effect of a prebiotic mixture of galacto- and long chain fructo-oligosaccharides on the incidence of atopic dermatitis (AD) during the first six months of life in formula fed infants at high risk of atopy. METHODS Prospective, double...

Rationale: Adults with atopic dermatitis (AD) have an increased risk for thromboembolic events. Clotting factors been shown to impact Staphylococcus aureus (S. aureus) colonization. However, the interplay between pediatric AD, thrombin, and S. remain under investigated. Methods: To assess thrombin in AD we performed a plasma generation assay on samples from Mechanisms of Progression Atopic Derm...

BACKGROUND Several previous studies have suggested the improvement of atopic dermatitis (AD) in response to special fabrics. In particular, beneficial effects have been reported, following the use of anion textiles. OBJECTIVE The purpose of this study is to evaluate the effectiveness and safety of an anion textile in patients suffering from AD. METHODS We compared an anion textile with a pu...

BACKGROUND Outcome measures for atopic dermatitis (AD) patients with pigmented skin have neither been developed nor validated. OBJECTIVE To compare the reliability and validity of four common AD outcome measures in patients with various levels of skin darkness. METHOD The inter- and intra-rater reliability and construct validity of the EASI (Eczema Area and Severity Index), objective-SCORin...

Atopic dermatitis (AD) is a chronic, inflammatory, pruritic skin disease with increasing prevalence. The etiopathogenesis of atopic dermatitis is multifactorial and involves a complex interplay of environmental and genetic factors that induce derangements in the structure and function of the epidermal barrier and immune system. Due to great heterogeneity of etiopathogenesis, there is also great...

Atopic dermatitis (AD) is a common inflammatory skin disorder mediated by inflammatory cells, such as macrophages and mast cells. Rifampicin is mainly used for the treatment of tuberculosis. Recently, it was reported that rifampicin has anti-inflammatory and immune-suppressive activities. In this study, we investigated the effect of rifampicin on atopic dermatitis in vivo and in vitro. AD was i...

Atopic dermatitis (AD) is one of the most common chronic relapsing in lammatory skin and allergic diseases [1-3]. AD refers to socially signi icant diseases. This disease retains its clinical signs for many years, it is often transformed into bronchial asthma with a severe atopic syndrome or into a systemic disease damaging not only the skin, but also internal organs such as digestive, respirat...