نتایج جستجو برای: atomoxetine

تعداد نتایج: 721  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
E J Marijke Achterberg Linda W M van Kerkhof Ruth Damsteegt Viviana Trezza Louk J M J Vanderschuren

Positive social interactions during the juvenile and adolescent phases of life, in the form of social play behavior, are important for social and cognitive development. However, the neural mechanisms of social play behavior remain incompletely understood. We have previously shown that methylphenidate and atomoxetine, drugs widely used for the treatment of attention-deficit hyperactivity disorde...

2017
Genevieve M. Hale

Objective: To review the efficacy and safety of pharmacological and nonpharmacological strategies used to treat primary orthostatic hypotension (OH). Data Sources: A literature review using PubMed and MEDLINE databases searching hypotension, non-pharmacological therapy, midodrine, droxidopa, pyridostigmine, fludrocortisone, atomoxetine, pseudoephedrine, and octreotide was performed. Study Selec...

2015
Rongwang Yang Weijia Gao Rong Li Zhengyan Zhao

BACKGROUND With early initiation of thyroxine supplementation, children with congenital hypothyroidism (CH) retain some subtle deficits, such as attention and inhibitory control problems. This study assessed the effects of atomoxetine on cognitive functions in treatment of attention deficit hyperactivity disorder (ADHD) symptoms in children with CH. METHODS In a 6-month, open-labeled pilot st...

Journal: :Health economics 2017
Jason Shafrin Anshu Shrestha Amitabh Chandra M Haim Erder Vanja Sikirica

Differences in patient characteristics across trials may bias efficacy estimates from indirect treatment comparisons. To address this issue, matching-adjusted indirect comparison (MAIC) measures treatment efficacy after weighting individual patient data to match patient characteristics across trials. To date, however, there is no consensus on how best to implement MAIC. To address this issue, w...

2016
Soo-Young Bhang Jun-Won Hwang Young-Sook Kwak Yoo Sook Joung Soyoung Lee Bongseog Kim Seok Han Sohn Un Sun Chung Jaewon Yang Minha Hong Geon Ho Bahn Hyung Yun Choi In-Hwan Oh Yeon Jung Lee

We evaluated the differences in utilization patterns including persistence and adherence among medications in children and adolescents with attention deficit hyperactivity disorder (ADHD). The current study was performed using data from the Korean Health Insurance Review and Assessment claims database from January 1, 2009 to December 31, 2013. Our study sample consisted of 10,343 children and a...

Journal: :Journal of child and adolescent psychopharmacology 2007
Thomas J Spencer Christopher J Kratochvil R Bart Sangal Keith E Saylor Charles E Bailey David W Dunn Daniel A Geller Charles D Casat Robert S Lipetz Rakesh Jain Jeffrey H Newcorn Dustin D Ruff Peter D Feldman Amanda J Furr Albert J Allen

OBJECTIVE To examine the effects on growth of long-term pharmacological treatment for attention-deficit/hyperactivity disorder (ADHD), we present findings from an ongoing 5-year study of the efficacy and safety of treatment with atomoxetine. METHODS North American patients, 6-17 years old at study entry (N = 1,312) and with Diagnostic and Statistical Manual of Mental Disorders,4th edition (DS...

Journal: :Neuroreport 2012
Oliver Höffken Melanie Lenz Nicole Höckelmann Hubert R Dinse Martin Tegenthoff

Paired-pulse paradigms are common tools to explore excitability in the human cortex. Although the underlying mechanisms of intracortical inhibition and facilitation in the motor system assessed by paired transcranial magnetic stimulation are well understood, little is known about the physiology of excitability in the human cortex measured by paired-pulse visual-evoked potentials (VEPs). We ther...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2017
Weize Huang Mariko Nakano Jennifer Sager Isabelle Ragueneau-Majlessi Nina Isoherranen

Physiologically based pharmacokinetic (PBPK) modeling of drug disposition and drug-drug interactions (DDIs) has become a key component of drug development. PBPK modeling has also been considered as an approach to predict drug disposition in special populations. However, whether models developed and validated in healthy populations can be extrapolated to special populations is not well establish...

2006
Nicholas Seneca Balázs Gulyás Andrea Varrone Magnus Schou Anu Airaksinen Francois Vandenhende William Kielbasa Lars Farde Robert B. Innis Christer Halldin

Rationale Atomoxetine is a potent and selective norepinephrine transporter (NET) reuptake inhibitor acting as a nonstimulant for the treatment of attention-deficit/hyperactivity disorder (ADHD). Previous positron emission tomography (PET) studies had failed to demonstrate the feasibility of measuring a dose-dependent and saturable NET occupancy in human brain using [C]MeNER. Objectives To deter...

2016
Evelina A. Zimovetz Stephen M. Beard Paul Hodgkins Matthias Bischof Josephine A. Mauskopf Juliana Setyawan

BACKGROUND An economic analysis from the perspective of the UK National Health Service (NHS) evaluated the cost effectiveness of lisdexamfetamine dimesylate (LDX) compared with atomoxetine in children and adolescents with attention-deficit/hyperactivity disorder who have had an inadequate response to methylphenidate. METHODS A 1-year decision-analytic model was constructed, with the health ou...

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