background: acute lymphoblastic leukemia (all) constitutes a heterogeneous group of diseases characterized by abnormal proliferation and accumulation of immature lymphoblasts arrested at various differentiation stages. increasing evidence suggests that chromosomal defects are present in these patients. the aim of this study is to investigate the chromosomal radiosensitivity in a group of all pa...

The discovery of multiple signaling cascades downstream of Atm may lead to a clearer understanding of the diverse defects seen in ataxia-telangiectasia. These pathways - which include evolutionarily conserved Chk1 and Atr, and non-conserved p21, p53 and AbI - guard genomic integrity after DNA damage.

This paper recounts the tale of a most vicious dragon that ate thousands of people every day, and of the actions that the king, the people, and an assembly of dragonologists took with respect thereof.