Benefits of microprocessor-controlled prosthetic knees (MPKs), such as significant reductions in falls and other important safety-related parameters, function, and mobility, have been well established in community ambulators (Medicare Functional Classification Level [MFCL]-3) with a transfemoral amputation (TFA). Little is known whether lowerfunctioning individuals (MFCL-2) with a TFA, who make...

The activating molecule in Beclin-1-regulated autophagy (Ambra1), also known as autophagy/Beclin-1 regulator 1, is a highly intrinsically disordered and vertebrate-conserved adapter protein that is part of the autophagy signaling network. It acts in an early step of mammalian target of rapamycin complex 1 (mTORC1)-dependent autophagy by favouring formation of the autophagosome core complex. How...

ersonal digital assistants (PDAs) combined with wireless networking are beginning to let mobile users access the same information they once used only from the office or at home. However, researchers have long realized that it's important not to treat mobile computing simply as a scaled-down version of desktop computing. Rather, mobility has profound consequences for the way in which we use comp...

Tetraspanins are a family of proteins with four transmembrane domains that play a role in many aspects of cell biology and physiology; they are also used by several pathogens for infection and regulate cancer progression. Many tetraspanins associate specifically and directly with a limited number of proteins, and also with other tetraspanins, thereby generating a hierarchical network of interac...

The gene encoding the adenomatous polyposis coli protein (APC) is mutated in most colon cancers. The major role of APC is thought to be as a scaffold for a protein complex that regulates the phosphorylation and thus degradation of β-catenin in the WNT signalling pathway (Huelsken and Behrens, 2002). However, there is increasing evidence that dysregulation of β-catenin is not the only effect of ...

We examined balance problems in athletes with acute lateral ankle sprains by recruiting 30 male athletes with right dominant side and traumatic ankle sprain through simple nonprobability sampling. We measured their sway index and limits of stability with the Biodex Balance System under different conditions. Our results showed that balance ability in patients with acute lateral ankle sprain was ...

As a network or cyber security experimenter, have you ever wished for an ability to analyze your experiment with high-level questions such as “did my experiment run as expected?” or “did X occur in my experiment?” Have you ever felt the tedium of manual analysis or writing problem-specific tools for every situation and wished for a better approach? Read on as ThirdEye might just be the right to...

Neurofilaments (NFs) are intermediate filaments with a diameter of 10 nm, similar to that of neurons. Although they are present in perikarya and dendrites, neurofilaments are particularly abundant in axons, where they are essential for the radial growth of axons during development, the maintenance of axon caliber and the transmission of electrical impulses along axons, i.e. velocity of nerve co...

The Arf small G proteins regulate protein and lipid trafficking in eukaryotic cells through a regulated cycle of GTP binding and hydrolysis. In their GTP-bound form, Arf proteins recruit a specific set of protein effectors to the membrane surface. These effectors function in vesicle formation and tethering, non-vesicular lipid transport and cytoskeletal regulation. Beyond fundamental membrane t...