Introduction: It was shown in a previous study, that MCPIP, a cilostamide derivative, increased atrial contraction force without changing contraction rate. To improve this property, two new derivatives of cilostamide were synthesized and their effects on PDE3 activity and isolated rat atria contraction were investigated. Methods: The inhibitory effect of each compound on PDE3 enzyme was dete...

Agreeing on a common value among set of agents is fundamental problem in distributed computing, which occurs several variants: In contrast to exact consensus, approximate variants are studied systems where agreement not possible or required, e.g., human-made control and the analysis natural systems, such as bird flocking opinion dynamics. We study time complexity two classical problems: non-ter...

This paper aims to propose a significant way of remote access and real time monitoring of a particular geographic area by integrating wireless sensor clouds with existing Telecom infrastructure and applications built around them through a gateway. This utility is very potent for environment monitoring in harsh and inaccessible places like mines, nuclear reactors, etc. We demonstrate a scaled do...

Owing to the fact that general semiparametric inference procedures are still underdeveloped for multivariate interval-censored event time data, we propose semiparametric maximum likelihood estimation for the gamma-frailty Cox model under mixed-case interval censoring. We establish the consistency of the semiparametric maximum likelihood estimator (SPMLE) for the model parameters, including the ...

The efficiency of a Markov sampler based on the underdamped Langevin diffusion is studied for high dimensional targets with convex and smooth potentials. We consider classical second-order integrator which requires only one gradient computation per iteration. Contrary to previous works similar samplers, dimension-free contraction Wasserstein distances convergence rate total variance distance ar...

‎this paper deals with the singular sturm-liouville expressions‎ ‎$ ‎ell y =‎ -‎y''+q(x)y=lambda y‎ ‎$‎ ‎on a finite interval‎, ‎where the potential function $q$ is real and‎ ‎has a singularity inside the interval‎. ‎using the asymptotic estimates of a‎ ‎spectral fundamental system of solutions of sturm-liouville‎ ‎equation‎, ‎the asymptotic form of the solution of the‎ ‎equation (0.1) and the ...

‎This paper deals with the singular Sturm-Liouville expressions‎ ‎$ ‎ell y =‎ -‎y''+q(x)y=lambda y‎ ‎$‎ ‎on a finite interval‎, ‎where the potential function $q$ is real and‎ ‎has a singularity inside the interval‎. ‎Using the asymptotic estimates of a‎ ‎spectral fundamental system of solutions of Sturm-Liouville‎ ‎equation‎, ‎the asymptotic form of the solution of the‎ ‎equation (0.1) and the ...

Timing is often seen as the most important property of systems after function, and safety-critical systems are no exception. In this paper, we consider how timing is typically treated in safety assurance and, in particular, the safety arguments being proposed by industry and academia. A critique of these arguments is performed based on how systems are generally developed and how evidence is gat...