Resistance to aspirin and its cytotoxicity significantly limits its therapeutic applications. Nano-liposomal encapsulation of aspirin can reduce its cytotoxicity. In this study, aspirin encapsulated nano-liposomes (AS-NL) was prepared and its performance in drug delivery and cytotoxicity was evaluated. The effects of two independent variables including: number of freeze/thawing cycles and conce...

objective: to determine the effects of pre-injury consumption of anti-platelet agents on the 30-day outcomes of patients with mild traumatic brain injury (tbi). methods: this prospective cohort study was conducted at three general hospitals in tehran, iran between july 2013 and july 2014. the study population included all patients with mild tbi aged over 18 years that medicated with aspirin or ...

this study was conducted to investigate the effects of dietary influence of aspirin on growth performance, antioxidant status and mortality in the broilers subjected to cold-induced ascites. a total six hundred 1-d old male broilers (ross, 308) were randomly allotted to four treatment groups, with five replicate pens per treatment and 30 birds each. the experimental groups were kept in a cold c...

myocardial infarction (mi) is one of the most important health burdens worldwide. aspirin as an non- steroid anti—inflammatory drug, has been proven to be a protective factor to decrease the incidence, however its effect of mi size is still unknown. we designed this study to compare the biomarkers after mi in patients with and without aspirin intake. 378 patients were enrolled and the results s...

aspirin is one of the certified medicines commonly used for the secondary prevention of myocardial infarction (mi). aspirin side effects and gastrointestinal bleeding, in particular, have arisen debates on its use for the primary prevention of mi. the present research evaluates the cost-effectiveness of the use of aspirin in the primary prevention of mi among iranian men with average cardiovasc...

renal artery stenosis (ras) is the most common cause of secondary hypertension. preliminary data indicate that aspirin renography with hippurate may be more sensitive for detection ras. in this study 20 patients with known or suspected ras underwent aspirin renography (20 mg/kg orally 1 hour before injection of radiotracer) and captopril renography (50 mg orally) with 99mtc-dtpa. renal angiogra...

Anti-platelet agents such as aspirin and dipyridamole are main factors to prevent stroke in high-risk people. Pentoxyphiline has been reported as a red blood cell aggregation antagonist to prevent stroke. We evaluated the role of pento-xyphiline as an adjunct therapy to decrease risk of stroke in patients who were under treatment with aspirin or dipyridamole. A 5-years open labeled clinical tri...

it  is  well  known  that  desensitization  treatment  with  aspirin  can  significantly  improve symptoms and quality of life in patient with aspirin-exacerbated respiratory disease. however, its mechanism has not been clearly understood yet. in this case report, 41-year-old male patient was referred to our allergy and immunology department with complaints of chronic rhinosinusitis including p...