Introduction: N-methyl-D-aspartate (NMDA) receptors play a pivotal role in the development of tolerance and physical dependence to opiates. Activation of NMDA receptors involves the induction of long term potentiation (LTP) in hippocampus. Our previous study suggested that chronic oral administration of morphine enhanced NMDA dependent LTP in the CA1 area of hippocampal slices of rats. The p...

Abbreviations: VGKC: Voltage-gated Potassium Channel; NMDAR: N-methyl, D-aspartate Receptor; LGI 1: Leucin-Rich Glioma-Inactivated-1; CASPR 2: Contact in-Associated Protein-2; SE: Status Epilepticus; WBC: White Blood Count; ALT: Alanine Transaminases; AST: Aspartate Transaminases; HSV-1: Herpes Simplex Virus; PCR : Polymerase Chain Reaction; EEG: Electro Encephalogram; CT: Computed Tomography; ...