FoxO transcription factors and sirtuin family deacetylases regulate diverse biological processes, including stress responses and longevity. Here we show that the Caenorhabditis elegans sirtuin SIR-2.4--homolog of mammalian SIRT6 and SIRT7 proteins--promotes DAF-16-dependent transcription and stress-induced DAF-16 nuclear localization. SIR-2.4 is required for resistance to multiple stressors: he...

A Z2 orbifold compactification of the heterotic string is considered. The resulting 6D GUT groups can be SO(16) or E7 × SU(2) plus some hidden sector groups. The N = 4 supersymmetry is reduced to N = 2. In particular, the SO(16) 6D model with one spinor representation 128 can reduce to the previous 5D SO(16) or SO(14) family unification models after compactifying the sixth dimension. To obtain ...

This problem set essentially reviews Markov chains and Poisson Processes. Not all exercises are to be turned in. Only those with the sign F are due on Thursday, November 16 at the beginning of the class. Although the remaining exercises are not graded, you are encouraged to go through them. We will discuss some of the exercises during discussion sections. Please feel free to point out errors an...

• Planning the coordinated motion of a group of agents who wish to move to a specified location amidst many obstacles • Planning the motion of an articulated skeletal model subject to constraints, such as maintaining hand contact with a door handle or avoiding collisions while passing through through a narrow passageway • Planning the motion of a character while navigating through a dense crowd...

Acute myeloid leukemia (AML) refers leukemias that arise from a myeloid precursor in the bone marrow. There is a high incidence of relapse, which has prompted research into various postremission strategies using either allogeneic (allo) or autologous hematopoietic stem cell transplantation (HSCT). HSCT refers to a procedure that infuses hematopoietic stem cells i to restore bone marrow function...

Substantial progress has been made in our understanding of the molecular and cellular bases of T cell mediated anti-tumor responses. T cells are potent effectors of the adaptive anti-tumor immune response. Some target antigens recognized by tumorreactive CD8+ T cells are non-mutated self-antigens that are also expressed by tumor cells. The molecular signals that modulate T-cell activation, func...

The grassland ecosystem in the Northern-Tibet Plateau (NTP) of China is verysensitive to weather and climate conditions of the region. In this study, we investigate thespatial and temporal variations of the grassland ecosystem in the NTP using theNOAA/AVHRR ten-day maximum NDVI composite data of 1981-2001. The relationshipsamong Vegetation Peak-Normalized Difference Vegetation Index (VP-NDVI) a...

As the outer surface of a nanoporous carbon is treated with 16-mercaptohexadecanoic acid, the carbon particles can form a stable suspension in water. When the water phase is compressed, the liquid infiltration behavior in the nanopores becomes significantly different from that of untreated material, suggesting that the inner surface is also modified. After the treatment, the infiltration pressu...

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The objective was to compare pharmacological strategies aiming to inhibit prostaglandin F2 alpha (PGF(2α)) synthesis (flunixin meglumine; FM), stimulate growth of the conceptus (recombinant bovine somatotropin; bST) and progesterone (P(4)) synthesis (human chorionic gonadotropin; hCG), as well as their combinations, regarding their ability to improve pregnancy rates in beef cattle. Lactating Ne...