OBJECTIVES Transcatheter aortic valve implantation (TAVI) does not enable concomitant or simultaneous ascending aortic intervention. This investigation evaluates the safety of TAVI in patients with ascending aortic dilatation and demonstrates mid-term follow-up. METHODS From November 2007 to December 2012, among 1143 patients with severe aortic stenosis screened for TAVI, a cohort of 457 pati...

background: previous researches about the effects of epididymal obstruction on the testes are contradictory, and the mechanism harmful effect of male duct system obstruction on seminiferous tubules still remains unclear. objective: the aim of this study was to investigate the effects of epididymal obstruction in prepubertal rats on the testis. materials and methods: 15 days of age, the young ra...

background: ciprofloxacin is a commonly prescribed antibiotic in the treatment of genitourinary tract infection. objective: the aim of this study was to investigate the effects of ciprofloxacin on testis apoptosis and sperm parameters in rat. materials and methods: twenty male wistar rats were selected and randomly divided into two groups; control (n=10) and experimental (n=10). the experimenta...

background: the global prevalence of diabetes mellitus is on rise. diabetes-induced oxidative stress has been known to affect liver, pancreas, kidney and reproductive organs pathologically. honey is a natural product of bee with antioxidant properties. objective: current study aimed to analyze the protective effects of metformin (mf) alone and mf+ natural honey co-administration on diabetes-ind...

The testis has long enjoyed a reputation as an immunologically privileged site based on its ability to protect auto-antigenic germ cells and provide an optimal environment for the extended survival of transplanted allo- or xeno-grafts. Exploration of the role of anatomical, physiological, immunological and cellular components in testis immune privilege revealed that the tolerogenic environment ...

During testis development, the rapid morphological changes initiated by Sry require the coordinate integration of many signaling pathways. Based on the established role of the platelet-derived growth factor (PDGF) family of ligands and receptors in migration, proliferation, and differentiation of cells in various organ systems, we have investigated the role of PDGF in testis organogenesis. Anal...

The direction of gonadal development is established through the predominance of one of two sex-determining pathways in bipotential gonads. When Sry is expressed, the male pathway prevails and a series of prominent changes in morphology and function of the gonad lead to testis differentiation. In the absence of Sry, the female pathway gains control of gonadal development, resulting in a lack of ...

quantum dots are new types of fluorescent materials for biological labeling. as a result, qds toxicity study is an essential requirement for future clinical applications. therefore, the cytotoxic cdse:zns quantum dots effects on some organs in mice are presented in this study. in this work, 10, 20 and 40 mg/kg doses of cdse:zns quantum dots were injected to 32 adult male mice. structural and op...

UNLABELLED To compare the efficacy of sono-urethrogram and ascending urethrogram in the evaluation of stricture urethra. MATERIALS AND METHODS In this prospective study 40 patients with obstructive lower urinary tract symptoms and suspected to be having stricture urethra were subjected to ascending urethrogram and sonourethrogram. The radiologist was blinded to the findings of ascending ureth...

Taphozous longimanus (Hardwicke) is a continuous breeder as males show full spermatogenic activity throughout the year. Microscopic study of testis reveals that immature, pre-breeding and sexually active males occur round the year. The testis shows variations in its structure during the different stages of breeding activity. In the pre-breeding period, testis shows various stages of spermatogen...