BACKGROUND Previous studies, which relied on hypothetical cases and chart reviews, have questioned the inter-rater reliability of the ASA physical status (ASA-PS) scale. We therefore conducted a retrospective cohort study to evaluate its inter-rater reliability and validity in clinical practice. METHODS The cohort included all adult patients (≥18 yr) who underwent elective non-cardiac surgery...

Understanding how the fruit microclimate affects ascorbate (AsA) biosynthesis, oxidation and recycling is a great challenge in improving fruit nutritional quality. For this purpose, tomatoes at breaker stage were harvested and placed in controlled environment conditions at different temperatures (12, 17, 23, 27 and 31 °C) and irradiance regimes (darkness or 150 µmol m(-2) s(-1)). Fruit pericarp...

Acetylsalicylic acid (ASA) is a nonsteroidal anti-inflammatory drug that can cause mast cell dependent diseases in sensitive individuals. ASA induced asthma is believed to be related to an overproduction of cysteinyl leukotriene C4 (LTC4) secondary to cyclooxygenase inhibition. It remains to be elucidated whether and by which mechanisms ASA may also influence systemic anaphylactic reactions. In...

OBJECTIVE To determine whether preoperative aspirin-acetylsalicylic acid (ASA)-timing or dose independently affects 30-day all-cause mortality. BACKGROUND Preoperative ASA administration is associated with reduced morbidity and mortality after coronary artery bypass graft (CABG). However, data are lacking regarding optimal timing and dosing of ASA. METHODS We retrospectively reviewed data f...

Objectives Melatonin, an important hormone secreted by the epiphysis, is a powerful anti-oxidant with a high potential to neutralize medical toxins. The goal of this study was to demonstrate the beneficial effect of melatonin on epididymal sperm and reproductive parameters in mice treated with acetylsalicylic acid (ASA). Materials and Methods Male adult mice were divided into four treatment g...

Nitric oxide-donating aspirin (NO-ASA) represents class of promising chemopreventive NO-NSAIDs. NO-ASA combines the beneficial effects of ASA and the gut-sparing effect of the NO moiety. There is, however, limited information on its pharmacokinetic and pharmacodynamic effects in vivo. Herein, experiments were designed to identify the optimal dose, the effective route of administration, and targ...

I . INTRODUCTION It is well known that L-ascorbic acid (AsA) has multifarious functions in our body. Humans who are unable to synthesize AsA in vivo have to absorb it as an essential nutrient from foods and some supplements. However, AsA is easily oxidized by oxygen in aqueous solutions, followed by oxidative degradation. To improve such instability, some derivatives including monoor di-substit...