to assess the effects of different fat supplements (palm oil, soybean oil or complete roasted soybean) to the transition period diets on holstein dairy cows, 30 multiparous holstein cows (fourth parity) with 794±41 kg of body weight and 250±10 days of pregnancy were, randomly, attributed to experimental diets including palm oil (treatment 1), soybean oil (treatment 2) or roasted whole soybean, ...

BACKGROUND In other neurological diseases, the failure to translate pre-clinical findings to effective clinical treatments has been partially attributed to bias introduced by shortcomings in the design of animal experiments. OBJECTIVES Here we evaluate published studies of interventions in animal models of multiple sclerosis for methodological design and quality and to identify candidate inte...

BACKGROUND Leptomeningeal metastasis is a consequence of advanced solid malignancies and has limited treatment options. It is possible that it is becoming more common as the leptomeninges act as a sanctuary site for recurrence from systemic cancer. METHODS Potential targeted and immunotherapy agents for the most common types of solid-tumor leptomeningeal metastasis are reviewed, as are their ...

the aim of this study was to evaluate the effects of three lighting programs on immune system and performance of broiler chickens. a total of 288 seven day-old male broiler chicks (ross-308) were randomly distributed between three treatments. each group was housed in the separated room with eight pen and 12-birds per pen. the management conditions were similar for all treatments throughout the ...

Sepsis is a systemic inflammatory response to infection. Sepsis, which can lead to severe sepsis, septic shock, and multiple organ dysfunction syndrome, is an important cause of mortality. Pathogenesis is extremely complex. In recent years, cell hypoxia caused by mitochondrial dysfunction has become a hot research field. Sepsis damages the structure and function of mitochondria, conversely, mit...

An experimental model based on kainic acid (KA) injections replicates many phenomenological features of human temporal lobe epilepsy, the most common type of epilepsy in adults. Taurine, 2-aminoethanesulfonic acid, present in high concentrations in many invertebrate and vertebrate systems, is believed to serve several important biological functions. In addition, it is believed to have a neuropr...

Most data for evaluating and training recommender systems is subject to selection biases, either through self-selection by the users or through the actions of the recommendation system itself. In this paper, we provide a principled approach to handling selection biases, adapting models and estimation techniques from causal inference. The approach leads to unbiased performance estimators despite...