Highly regioselective ring-opening coupling reactions of diarylmethylenecyclopropa[b]naphthalenes with Grignard reagents have been developed, which provide differently substituted β-vinylic naphthalenes in moderate to excellent yields.

An investigation of the new synthetic method to synthesize regioregular, head-to-tail coupled poly(3-alkylthiophenes) using magnesium-halogen exchange (Grignard metathesis) called the GRIM method is described. Treatment of 2,5-dibromo-3-alkylthiophenes with a variety of alkyl and vinyl Grignard reagents resulted in two metalated, regiochemical isomers, namely, 2-bromo-3-alkyl-5-bromomagnesiothi...

The possibility of generating MgH(2) nanoparticles from Grignard reagents was investigated. To this aim, five Grignard compounds, i.e. di-n-butylmagnesium, tert-butylmagnesium chloride, allylmagnesium bromide, m-tolylmagnesium chloride, and methylmagnesium bromide were selected for the potential inductive effect of their hydrocarbon group in leading to various magnesium nanostructures at low te...

The use of steroid hormones containing tagged atoms promises to have an important part in the study of their metabolism. The relative availability of radioactive Cl4 manufactured in the uranium chain-reacting pile at Oak Ridge has facilitated the synthesis of such compounds containing labeled carbon atoms (1). Through the cooperation of Dr. Konrad Dobriner of the Sloan-Kettering Institute for C...

Grignard Compounds RMgX (R=organic group; X=Cl, Br, I) are common tools in inorganic and organic synthesis. The structure of these substances in solution, however, is unknown. To answer this question we performed EXAFS measurements at the Br-K-edge in absorption mode and at the Mg-K-edge in fluorescence mode. Rom these complementary data a consistent model of the structure of the investigated G...

Grignard reagents are used as intermediates in the production of complex molecules, since they can be to form new carbon-carbon bonds, e.g. formation active pharmaceutical ingredients....