Seventy-three N,N-disubstituted amides of long-chain, principally C(18), fatty acids were screened for antimicrobial activity against bacteria, yeasts, and molds. Amides containing an epoxy group exhibit a broad spectrum of antimicrobial activity which is further enhanced by unsaturation. Mono-unsaturation alone does not contribute a broad level of activity to the N,N-disubstituted amides of th...

The Action of Liquid-Ammonia Solutions of Ammono Acids on Metallic Amides, Imides, and Nitrides. The acid amides and imides, and the metallic derivatives of the acid amides and imides are the acds, bases, and salts respectively of an ammonia system of acids, bases, and salts.1 Guided by the relationships implied in the above statement Franklin and Stafford were able to prepare potassium derivat...

We have developed a one-pot method for the direct intermolecular reductive hydroxyalkylation or alkylation of amines using lactones or esters as the hydroxyalkylating/alkylating reagents. The method is based on the in situ amidation of lactones/esters with DIBAL-H-amine complex (for primary amines) or DIBAL-H-amine hydrochloride salt complex (for secondary amines), followed by reduction of the ...

The functional group transformation associated with nitrile moiety is considered a diligent research topic in the synthetic community as it building block for several organic molecules, including ketones and amides. Many methodologies have been developed synthesizing amides, considering them analogues exciting biological properties. However, there are limited articles to synthesize these import...

Nucleophilic addition of the chiral lithium enolates of (S)-(−)-4-benzyl-2-oxazolidinone acetamide with N-tosyl arylaldehyde imines gives -aryl-amino acid derivatives in good yields and excellent diastereoselectivity. © 2002 Elsevier Science Ltd. All rights reserved. -Amino acids and their derivatives have attracted considerable attention in recent years due to their occurrence in biologically ...

Kinetically unstable isocyanides as vinyl, allenyl and propargyl react in Passerini Ugi reactions faster than they decompose lead to functionalized α-acyloxy amides α-amino amides, respectively, which can subsequently be used involving the unsaturated substituent.

We report the first one-pot reductive homocoupling reaction of secondary amides and cross-coupling reaction of secondary amides with ketones to give secondary vicinal diamines and amino alcohols. This method relies on the direct generation of α-amino carbon radicals from secondary amides by activation with trifluoromethanesulfonic anhydride, partial reduction with triethylsilane and samarium di...

A new method for synthesis of amides and hydroxamic acids from nitroarenes and aldehydes is described. The MnO2 catalyzed thermal deoxygenation of nitrobenzene resulted in formation of a reactive nitroso intermediate which on reaction with aldehydes provided amides and hydroxamic acids. The thermal neat reaction in the presence of 0.01 mmol KOH predominantly led to formation of hydroxamic acid ...