this study took an epidemiological approach toward the problem of drug addiction in tehran. the subjects were 300 addicts chosen on the basis of stratified random selection out of the population of 3627 prisoners who were all proven addicts and sentenced to imprisonment by the court in the year 1370. a descriptive survey showed that drug addiction generally, and heroin addiction specifically, i...

background: glucose-6-phosphate dehydrogenase (g6pd) deficiency is one of the most known enzyme defects in iran with various genetic mutations. we aimed to study the predisposing factors of hemolysis in children with g6pd deficiency. methods: this study was done during 2007-2012 in two referral centers of mofid children's hospital and baqiyatallah hospital, tehran, iran. the hospital records of...

hypothyroidism is one of the problems that can cause severe growth and developmental defects in children and infants. by using anticonvulsive drugs (phenobarbital, carbamazepine, navalproate , and phenytoin), liver microsomal enzymes will be increased and will lead to hypothyroidism in infants because of increasing metabolism of t3, and t4 by liver. the purpose of this study was to evaluate the...

objective in this study, we investigated the changes of the serum levels of thyroidhormones including thyroxine (t4), triiodothyronine (t3), t3 resin uptake andthyroid stimulating hormone (tsh) in epileptic children during treatment withanti-epileptic drugs (aeds) including carbamazepine (cbz), primidone (prm),phenobarbital and valproic acid (vpa). materials and methods this study consisted of ...

flecainide has been known to cause torsades de pointes (tdp) in patients with structural heart disease and its mechanism has been attributed to use-dependency. we present a patient with flecainide-induced tdp in the absence of any other precipitating factors.this case highlights potential reverse use dependence associated with flecainide resulting in tdp.

despite the introduction of new antifungal agents, resistances to antifungal therapy continue to increase and outcome of invasive fungal infections treatment is frequently suboptimal. a large amount of the recent effort in antifungal drug discovery has focused on a limited set of targets with functions known or expected to be important for fungal viability and virulence. a variety of techniques...

Overview Reports of sudden deaths of children and adolescents treated with psychotropic medications have raised concerns regarding the appropriateness of this therapy, as well as the advisability of baseline and periodic electrocardiographic (ECG) monitoring of such patients.1–4 What follows is a review of the drug effects on the ECG, cardiovascular effects of the commonly used psychotropic med...

A detailed study of the Counter-Rotating Model (CRM) for generic finite static axially symmetric thin disks with nonzero radial pressure is presented. We find a general constraint over the counter-rotating tangential velocities needed to cast the surface energy-momentum tensor of the disk as the superposition of two counter-rotating perfect fluids. We also found expressions for the energy densi...

We report the following TMS-related seizure or spell. The subject was a 22-year-old healthy woman who had no risk factors and was not taking any medications. She was screened using a self-report questionnaire for contraindications for TMS, including past or present neurologic, cardiac, and psychiatric conditions, family history of epilepsy, sleep deprivation, medicinal or recreational drug use,...

OBJECTIVE to investigate stressors perceived by patients in the immediate postoperative of cardiac surgery and their association with sociodemographic and clinical characteristics. METHOD a prospective correlational study conducted in a city in São Paulo, between August 2013 and December 2014. A non-probabilistic sample included patients submitted to their first coronary artery bypass graft o...