An autonomic reflex linking exercising skeletal muscle metabolism to central ventilatory control is thought to be mediated by neural afferents having free endings that terminate in the interstitial fluid of muscle. To determine whether changes in muscle extracellular fluid pH (pHe) can provide an error signal for exercise ventilatory control, pHe was measured during electrically induced contrac...

BACKGROUND Unexpected death within 24 hours of admission is a real challenge for the clinician in the emergency room. How to diagnose these patients and the right approach to prevent sudden death with 24 hours is still an enigma. The aims of our study were to find the independent factors that may affect the clinical outcome in the first 24 hours of admission to the hospital. METHODS We perfor...

Intermittent hypoxia (IH) resulting from sleep apnea can lead to pulmonary hypertension (PH) and right heart failure, similar to chronic sustained hypoxia (CH). Supplemental CO(2), however, attenuates hypoxic PH. We therefore hypothesized that, similar to CH, IH elicits PH and associated increases in arterial endothelial nitric oxide synthase (eNOS) expression, ionomycin-dependent vasodilation,...

BACKGROUND Pulmonary hypertension (PH) is an important lethal manifestation of systemic sclerosis (SSc). Evidence of an association between peripheral and pulmonary arterial vasculopathy in SSc has been demonstrated. We hypothesized that peripheral arterial stiffness could predict PH in SSc. METHODS We performed a cross-sectional study among patients with SSc who underwent Cardio-Ankle Vascul...

The acid-base equilibrium is closely linked to gas exchange in the lungs, and respiratory exchange ratios are used to evaluate respiratory effectiveness and tissue oxygen levels. Acid-base indicators are determined in both arterial and venous blood samples. This study compares the usefulness of acid-base indicators of venous and arterial blood in monitoring the condition of horses with recurren...

Right ventricular (RV) response to exercise or pharmacological stress is not well documented in pulmonary hypertension (PH). We investigated the relationship between RV reserve and ventricular-arterial coupling. Surgical ligation of the left pulmonary artery was performed in 13 Large White piglets (PH group), thereafter weekly embolisations of the right lower lobe were performed for 5 weeks. A ...

Rainbow trout (Oncorhynchus mykiss) survived in alkaline fresh water (pH = 9.50)for 72 h, although the exposure rendered thefish more susceptible to mortality from other causes. At pH 9.50 ammonia excretion (Jm,,) was initially blocked, and total plasma ammonia levels increased. However, Jamm steadily recovered thereafter; by 48 h control rates were reestablished and plasma total ammonia stabil...

Understanding how arterial remodeling changes the mechanical behavior of pulmonary arteries (PAs) is important to the evaluation of pulmonary vascular function. Early and current efforts have focused on the arteries' histological changes, their mechanical properties under in vitro mechanical testing, and their zero-stress and no-load states. However, the linkage between the histology and mechan...

Objective- This study aims to determine the efficacy of propofol in grass carp anesthesia and to examine the impact of the drug on electrocardiogram, pH and blood gases in this fish species. Design- Experimental study. Animals- 120 apparently healthy grass carps, weighting between 1-2 kg. Procedure- Fishes were sorted randomly into 12 groups of 10 fish each. Five groups were anesthetized by bat...

introduction: the effect of severe soft tissue injury on the severity of hemorrhagic shock is still unknown. therefore, the present study was aimed to determine hemodynamic and metabolic changes in traumatic/hemorrhagic shock in an animal model. methods: forty male rats were randomly divided into 4 equal groups including sham, hemorrhagic shock, soft tissue injury, and hemorrhagic shock + soft ...