Gamma-scintigraphy is applied extensively in the development and evaluation of pharmaceutical delivery systems, particularly for monitoring formulations in the gastrointestinal and respiratory tracts. The radiolabelling is generally achieved by the incorporation of an appropriate radionuclide such as technetium-99m or indium-111 into the formulation or by addition of a non-radioactive iso...

piroxicam, an anti-inflammatory drug, exhibits poor water solubility and flow properties, poor dissolution and poor wetting. consequently, the aim of this study was to improve the dissolution of piroxicam. microparticles containing piroxicam were produced by spray drying, using isopropyl alcohol and water in the ratio of 40:60 v/v as solvent system, and spray chilling technology by melting the ...

      The in vitro dissolution of plasma-sprayed hydroxyapatite (PHA) coatings with different characteristics, produced by various spraying conditions, in a Tris-buffered solution at pH 7.4 was experimentally studied through the measurement of calcium ions release with Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES), and then modeled. Three coating characteristics, th...

A new Soluplus (polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer)-based supersaturable self-emulsifying drug delivery system (S-SEDDS) was formulated to enhance oral absorption of tacrolimus (FK506) with minimal use of oil, surfactant, and cosurfactant. A high payload supersaturable system (S-SEDDS) was prepared by incorporating Soluplus, as a precipitation inhibitor,...

Local delivery of cancer chemotherapeutics enables sustained drug levels at the site of action thereby reducing systemic side effects. A novel insertable polymeric drug delivery system for cervical cancer treatment is presented. Cisplatin, the first line of therapy employed for cervical cancers, was incorporated in a poly(ethylene-co-vinyl acetate) (EVAc) device that is similar to those current...

Objective: The study aims to develop a Self-nanoemulsifying drug delivery system (SNEDDS) of Quercetin enhance its oral bioavailability.
 Methods: In the present study, was formulated into SNEDDS using various oils, surfactants, and co-surfactants. developed formulations were subjected studies like content analysis, droplet size thermodynamic stability, in vitro release studies.
 Resu...

The efficiency of plasmin, miniplasmin, and neutrophil leukocyte elastase in fibrin digestion is well characterized in static systems. Since in vivo the components of the fibrinolytic system are permanently exposed to flow, we have developed two in vitro models and studied the effect of shear forces on fibrin dissolution with these proteases. Cylindrical nonocclusive fibrin clots are perfused a...

A computer-controlled broad-beam ultrasound system is presented that accelerates struvite stone chemolysis in vitro. Hemiacidrin chemolysis was greatly potentiated and was linearly dependent on stone surface area and total ultrasound time. Dissolution also was dependent on citric acid concentration and solution pH, with only minimal dissolution above pH 4.2. Citrate concentrations of 12% provid...