A growing body of literature describes how human pathogens in the environment acquire antibiotic resistance genes (ARGs), a process potentially boosted by selection pressure from antibiotics. Contaminated water and soil may then maintain and spread these antibiotic-resistant bacteria (ARB) and ARGs. A review in this issue of EHP examines strategies for reducing environmental pollution with anti...

Misuse and overuse of antibiotics have contributed to the rise antimicrobial resistance as one top public health threats. Antibiotics antibiotic genes (ARGs) are prevalent in agricultural soils due widespread application livestock organic wastes. However, information about occurrence, distribution, risk ARGs is lacking for many scenarios. In this study, based on 2225 observations from 135 indep...

Manure storage facilities are critical control points to reduce antibiotic resistance genes (ARGs) in swine manure slurry before the is land applied. However, little known about how exogenous chemicals entering may affect fate of ARGs. The objective this study was analyze impact six commonly used pit additives and four facility disinfectants on concentration ARGs slurry. Bench scale reactors, e...

The land application of animal manure can introduce microbiome and resistome to croplands where food crops are grown. objective this study was characterize the on in leaves lettuce grown manured soil identify main transmission routes microbes antibiotic resistance genes (ARGs) from episphere endosphere lettuce. Shotgun metagenomic results show that significantly altered composition surface soil...

Hospitals and wastewater treatment plants (WWTPs) are high-risk point sources of antibiotic-resistance genes (ARGs) antibiotic-resistant bacteria. This study investigates the occurrence clinically relevant ARGs (sul1, tet(B), blaCTX-M, blaNDM-1, qnrS) a class one integron (intI1) gene in urban rivers, hospitals, municipal Kathmandu Valley, Nepal. Twenty-five water samples were collected from th...

Members of the genus Aeromonas that commonly occur in various aquatic ecosystems are taken into account as vectors spreading antibiotic resistance genes (ARGs) in the environment. In our study strains of Aeromonas spp. (n = 104) not susceptible to ampicillin were isolated from municipal sewage of different levels of purification - raw sewage, activated sludge and treated wastewater. The crucial...

The spread of antibiotic-resistant pathogens and their resistance traits is an epic global challenge, as recognized by various international bodies, including the G8 Science Ministry in 2013 and the Elmau summit in 2015 While most attention continues to be devoted to the clinic and the need to develop new drugs, there is growing recognition of the need to understand the origin and ecology of an...

Shrimp aquaculture environments are a natural reservoir of multiple antibiotic resistance genes (ARGs) due to the overuse antibiotics. Nowadays, prevalence these kinds emerging contaminants in shrimp is still unclear. In this study, high-throughput sequencing techniques were used analyze distribution ARGs and mobile genetic elements (MGEs), bacterial communities, their correlations water sedime...

Despite of a high abundance antibiotics, heavy metals, and organic matters detected in the Saigon River Ho Chi Minh City, level spread antibiotic resistance genes this river are poorly understood. In study, total 10 (ARGs), including conferring to aminoglycosides (aac(6)-Ib-cr), β-lactam antibiotics (blaCTX-M, blaSHV, blaTEM), quinolones (qnrA, qnrB), sulfonamides (sul1, sul2), trimethoprim (df...