To the Editor: A recent AHA Scientific Statement on medication errors in acute cardiovascular care suggested that streamlined protocols and standardized order forms may be useful in reducing medical errors.1 We would like to draw attention to a potential danger of such measures, namely the erroneous application of tPA treatment protocols for acute myocardial infarction (MI) to patients with acu...

1 Siberian State Medical University, Tomsk, Russian Federation, 2 Tropical Disease Research Laboratory, Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, 3 Laboratory of Molecular Mechanisms of Pathological Processes, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation, 4 Department of Med...

Prototheca wickerhamii rarely causes systemic infection in humans but when it occurs, there are coexisting comorbidities. This case illustrated shows the manifestation of this opportunistic microorganism in an immunosuppressed patient. The patient was successfully treated with Liposomal amphotericin B with complete resolution of the lesions.

Background: Allosteric communications are vital for cellular signaling. Here we explore a relationship between protein architectural organization and shortcuts in signaling pathways. Results: We show that protein domains consist of modules interconnected by residues that mediate signaling through the shortest pathways. These mediating residues tend to be located at the inter-modular boundaries,...

Facial expression and direction of gaze are two important sources of social information, and what message each conveys may ultimately depend on how the respective information interacts in the eye of the perceiver. Direct gaze signals an interaction with the observer but averted gaze amounts to "pointing with the eyes", and in combination with a fearful facial expression may signal the presence ...

OBJECTIVES I analyzed traffic fatalities and homicides related to leaving home for routine activities, and considered connections between these fatalities and the built environment. METHODS I analyzed city, county, state, and federal data for traffic fatalities and homicides by strangers for 15 metropolitan areas, and classified deaths as occurring in the central city, in inner suburbs, or in...

The environmental noise level represents one of the key factors of life quality in urban areas of modern cities. A continuous monitoring of the noise levels and the analysis of results have become a necessity when we discuss a possible recovery of those areas with high levels of noise pollution, and particularly, those zones which were designed for specific activities, e.g., areas around hospit...

Over the past 5 years, parts of Oklahoma have experienced marked increases in the number of small- to moderate-sized earthquakes. In three study areas that encompass the vast majority of the recent seismicity, we show that the increases in seismicity follow 5- to 10-fold increases in the rates of saltwater disposal. Adjacent areas where there has been relatively little saltwater disposal have h...