Cortisol's daytime rhythm is thought to be altered by aging and by exposure to chronic stress. However, measurement of an individual's usual cortisol rhythm is hampered by the effects of acute stressors, by differences between working days and weekends, by between-day variation in waking time and sleep duration, by variability in cortisol sampling times, and by possible variability in the timin...

Simplified cultivation technologies for rice have become increasingly attractive in recent years in China because of their social, economical and environmental benefits. To date, several simplified cultivation technologies, such as conventional tillage and seedling throwing (CTST), conventional tillage and direct seeding (CTDS), no-tillage and seedling throwing (NTST), no-tillage and direct see...

Species distribution modeling was used to determine factors among the large predictor candidate data set that affect the distribution of Muscari latifolium, an endemic bulbous plant species of Turkey, to quantify the relative importance of each factor and make a potential spatial distribution map of M. latifolium. Models were built using the Boosted Regression Trees method based on 35 presence ...

Using AUC-based dosing compensates for variations in renal function between and within individual patients. It does not adjust for other factors such as previous chemotherapy, previous radiotherapy, or performance status. One empiric method to adjust for these factors would be reduction of the ideal AUC. However, because AUC-based dosing accounts for variations in renal function, this would not...

Many current dose-response methods assume a parametric shape of some form and do not accommodate comparisons between methods. Motivated by a need to be able to compare dose-response curves without assuming a parametric shape to the dose-response curve, we applied our technique to model them by non-parametric smoothing methods and also estimate area under the curves. Given that we do not know th...

Methods This is an observational prospective cohort study. Population is composed of adults hospitalized in ICU of the Service of Burns near University Hospital Center, Tirana, Albania for 5 years(2010-2015).Patients are grouped according glucose values on three categories: Patients with Euglycemia ( 80-120 mg/dL), Moderate Hyperglycemia (121-180 mg/dL) and Critical Hyperglycemia (> 180 mg/dL )...

Colorectal cancer (CRC) is among the leading causes of cancer deaths and can be caused by environmental factors as well as genetic factors. Therefore, we developed a prediction model of CRC using genetic risk scores (GRS) and evaluated the effects of conventional risk factors, including family history of CRC, in combination with GRS on the risk of CRC in Koreans. This study included 187 cases (...

Genomic prediction shows promise for personalised medicine in which diagnosis and treatment are tailored to individuals based on their genetic profiles for complex diseases. We present a theoretical framework to demonstrate that prediction accuracy can be improved by targeting more informative individuals in the data set used to generate the predictors ("discovery sample") to include those with...