Introduction: Brorninated fwe suppressants are effective and widely used [1]. Due to their destruction of stratospheric ozone, however, the production of these chemicals was halted in January 1994. Although testing and development of possible substitutes is occurring [2], a repkcement with all of the desirable properdes of CF3Br (the most common fire suppressant) has yet to be identified. Conse...

Comment A number of cases of bilateral acute angle closure glaucoma associated with HIV have been reported.I The mechanism of angle closure is thought to be due to anterior rotation of the irislens diaphragm at the axis of the scleral spur secondary to an anterior uveal effusion. Cyclopentolate retracts the iris lens diaphragm posteriorly and therefore opens the angle. Relative pupillary block ...

Aqueous humor collected from freshly enucleated bovine eyes was passed over a gelatin affinity column, and bound material was eluted with 4M urea. When fractionated by sodium dodecyl sulfate electrophoresis, the eluted material co-migrated with human plasma fibronectin and protein standards of approximately 220,000 daltons. Amino acid analyses demonstrated a composition similar to that of human...

IN a previous investigation a significant difference was found in the pressure response of the living and dead eyes of individual rabbits when a given volume of fluid was injected into the eye (Eisenlohr and Langham, 1962). An increase in the intra-ocular pressure of living animals was found to force blood from the eye and the amount lost per unit pressure increase was found to reach a maximum ...

Flow resistance was measured as bovine and primate aqueous humor was passed through Nuclepore polycarbonate filters having flow dimensions similar to those found within the juxtacanalicular meshwork of the aqueous outflow network. The results indicate that aqueous humor has a greater flow resistance than isotonic saline; this greater resistance is attributable to proteins or glycoproteins in aq...

OBJECTIVES This 5-yr study assessed urate-lowering and clinical efficacy and safety of long-term febuxostat therapy in subjects with gout. The primary efficacy end-point was reduction to and maintenance of serum urate (sUA) levels < 6.0 mg/dl. METHODS Subjects who completed a previous 28-day study were entered into an open-label extension study and initially received febuxostat 80 mg daily. B...

OBJECTIVE To assess the effect of treatment with febuxostat versus placebo on joint damage in hyperuricemic subjects with early gout (1 or 2 gout flares). METHODS In this double-blind, placebo-controlled study, 314 subjects with hyperuricemia (serum uric acid [UA] level of ≥7.0 mg/dl) and early gout were randomized 1:1 to receive once-daily febuxostat 40 mg (increased to 80 mg if the serum UA...

Topical administration of 1% vanadate in a formulation designed to enhance penetration lowered intraocular pressure in monkeys' eyes. The decrease in intraocular pressure was associated with significant decreases in aqueous humor flow. Tonographic outflow facility was unaltered by topical vanadate.

FOR many years considerable attention has been focused on the problem of the origin and circulation ofthe aqueous humour under normal and pathological conditions. One of the methods applied to this study is the detection within the eye of dyes which enter the anterior chamber across the bloodaqueous baffler-a method first suggested by Ehrlich (1882) when he observed that fluorescein injected in...

PURPOSE The objective of the study was to compare the intraocular penetration levels of the newer fluoroquinolones, moxifloxacin, gatifloxacin, and levofloxacin in the rabbit's cornea, aqueous humor, and conjunctiva after topical instillation. METHODS 0.5% moxifloxacin, 0.3% gatifloxacin, and 0.5% levofloxacin were instilled in random sequence in both eyes of nine New Zealand White rabbits at...