Recently reported synthetic organic nanopore (SONP) can mimic a key feature of natural ion channels, i.e., selective ion transport. However, the physical mechanism underlying the K(+)/Na(+) selectivity for the SONPs is dramatically different from that of natural ion channels. To achieve a better understanding of the selective ion transport in hydrophobic subnanometer channels in general and SON...

I n prokaryotes, the major paradigm for signal transduction is the two-component regulatory system. The first component is a sensor kinase; it is phosphorylated on a histidine residue from cytoplasmic ATP. Many of these sensor kinases are inner membrane proteins with two transmembrane domains. The second component of such systems, the response regulators, often are two-domain proteins that func...

The porin-cytochrome (Pcc) protein complex is responsible for trans-outer membrane electron transfer during extracellular reduction of Fe(III) by the dissimilatory metal-reducing bacterium Geobacter sulfurreducens PCA. The identified and characterized Pcc complex of G. sulfurreducens PCA consists of a porin-like outer-membrane protein, a periplasmic 8-heme c-type cytochrome (c-Cyt) and an outer...

Good software architecture is critically important for successful software development. The software architecture can be defined as a set of architectural design decisions. However, the effort for acquiring good software architecture currently lacks of interest and experience in architectural design decisions. For this reason, during acquiring good software architecture, it is difficult to eval...

The title compound, [Co(C3H7NO)(H2O)5]SO4·C3H7NO, contains five aqua ligands, a Co(II) atom, a sulfate ion and both a coordinating and a non-coordinating di-methyl-formamide (DMF) mol-ecule. The DMF solvent mol-ecule lies between the complex units, which are located along the b axis. The sulfate ion is for charge balance. The Co(II) atom has distorted octa-hedral coordination geometry, being li...

conclusions it seems that besides the variety and prevalence of blatem and blactx, enormous mechanisms such as porin and leaking systems (efflux pumps) are responsible for the information of the a. baumannii resistance to disinfectants. the study on an accurate consideration of the resistance in strains and other microorganisms is advised. results in the current study, 131 a. baumannii isolates...

A carbapenem-resistant clinical isolate of Escherichia coli, which lacked OmpF and OmpC porins, carried a marR mutation and expressed a functional yedS, a normally nontranslated gene. MarR and YedS are described here as having effects on the ability of this strain to resist carbapenems. Additionally, expression of YedS was regulated by the small RNA MicF in a MarA-dependent way. These findings ...