نتایج جستجو برای: apoptotic protease activating factor 1 apaf 1
تعداد نتایج: 3426648 فیلتر نتایج به سال:
Once melanoma metastasizes, no effective treatment modalities prolong survival in most patients. This notorious refractoriness to therapy challenges investigators to identify agents that overcome melanoma resistance to apoptosis. Whereas many survival pathways contribute to the death-defying phenotype in melanoma, a defect in apoptotic machinery previously highlighted inactivation of Apaf-1, an...
Transection of the optic nerve induces an apoptotic degeneration of retinal ganglion cells (RGC) in the rat retina. The immediate early gene c-Jun, the proapoptotic Bcl-2 family member Bax and the apoptosome constituent Apaf-1 have been shown previously to play major roles in the induction or execution of the apoptosis cascade. In this study we have designed and generated short interfering RNAs...
Background on apoptosis Cell death can be achieved by two fundamentally different mechanisms, apoptosis and necrosis. Apoptosis is characterized by several morphological features that include condensation of nuclei and internucleosomal degradation of DNA, cell membrane blebbing, and formation of apoptotic bodies. By contrast, necrosis is recognized by swelling of the cell and organelles, follow...
Brain tumors are typically resistant to conventional chemotherapeutics, most of which initiate apoptosis upstream of mitochondrial cytochrome c release. In this study, we demonstrate that directly activating apoptosis downstream of the mitochondria, with cytosolic cytochrome c, kills brain tumor cells but not normal brain tissue. Specifically, cytosolic cytochrome c is sufficient to induce apop...
In This Issue In This Issue Zombie cells ooks can be deceiving—even a cell that appears healthy may be doomed to die. Ekert et al. (page 835) report that cells lacking two important caspases can survive in the short term without a growth factor, but will succumb eventually. Thus, the normal job of these caspases may be to accelerate the dying process rather than control the commitment of cells ...
In This Issue In This Issue Zombie cells ooks can be deceiving—even a cell that appears healthy may be doomed to die. Ekert et al. (page 835) report that cells lacking two important caspases can survive in the short term without a growth factor, but will succumb eventually. Thus, the normal job of these caspases may be to accelerate the dying process rather than control the commitment of cells ...
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