نتایج جستجو برای: apoptotic genes
تعداد نتایج: 470166 فیلتر نتایج به سال:
The Brn-3a transcription factor stimulates the expression of the anti-apoptotic Bcl-2 and Bcl-x proteins and protects neuronal cells from apoptosis. Here we show that a minimal Bcl-x promoter is activated by Brn-3a and that this stimulation is prevented by the pro-apoptotic p53 protein. Both these effects are mediated via Bcl-x promoter sequences, which are indistinguishable from those required...
Background and Aims: Epigallocatechin-3-gallate (EGCG) is a polyphenolic compound from green tea, which its anticancer effects on many types of cancers have been confirmed, but the molecular mechanism by which EGCG induces apoptosis remains unknown. The aim of the present study was to investigate anti-proliferative properties and apoptotic signaling pathway of EGCG on PC3 human prostate cancer ...
Introduction: Given to the fact that the high toxicity and side effects of chemotherapeutic drugs have limited their clinical use, it is not surprising that novel therapeutic drugs with less toxicity and more efficacy have entered into the novel protocols. Relatively, Melatonin, a main product of pineal gland, not only plays a key role in the regulation of circadian rhythm, but also exerts anti...
Background: The use of medicinal herbs in traditional medicine has been important and many of these plants have antioxidant, anti-inflammatory, antimicrobial and anti-cancer effects. Objective: The aim of this study was to evaluate the antibacterial and anti-cancer effects of Artemisia turcomanica extract on gastric cancer cell line (AGS) and its effect on expression of cyclin D1 and cyclin E g...
Idarubicin is a chemotherapeutic drug frequently used to treat breast cancer and acute leukemia. This study aimed immobilize idarubicin on glutaraldehyde (GA)-coated magnetic nanoparticles (MNP-GA) prepare with high stability low toxicity. We prefreed MNPS because of their easy synthesis, cost, non-toxicity. In the study, magnetite (Fe3O4) were prepared, coated glutaraldehyde, characterization ...
One of the most important mechanism by which bioflavonoids can exert their effects in cancer treatment, is through interaction with bio-macromolecules such as DNA. Recent literature emphasizes role Bavachinin (BVC) an emerging anticancer agent. However, there are no reports on its ability to interact The present study investigated DNA binding properties BVC many spectroscopic and computational ...
The prostate is a small gland located below the bladder and upper part of the urethra. In developed countries prostate cancer is the second common cancer (after skin cancer), and also the second leading cause of cancer death (after lung cancer) among men. The several studies have been shown prostate cancer familial aggregation. The main reason for this aggregation is inheritance included genes....
Background: Valproic acid (VPA), a branched short-chain fatty and histone deacetylase (HDAC) inhibitor, has diverse biological activities in human cells, including anti-cancer properties. Objectives: In the present study, we tested cytotoxicity of VPA on proliferation, cell cycle, apoptosis cervical cancer line, HeLa. Methods: HeLa line was cultured Dulbecco’s modified eagle medium (DMEM) effec...
In this study, cell death regulation and induction in AML line from a relapsed MLL-rearranged model (MOLM-13) was investigated with doxorubin (Dox) betulinic acid (BetA), singly combination. CyQUANT Direct® Annexin V/propidium iodide double staining were used to measure the cytotoxic effects of compounds, respectively. Reactive oxygen species (ROS) generation measured using 2′,7′-dichlorofluore...
BACKGROUND: Doxorubicin (DOX) is a drug that frequently used to treat variety of cancers. Unfortunately, in many situations, it ineffective, and raising the dosage restricted due systemic toxicity. An important strategy minimize toxic effects above cited use co-adjuvant. A citrus flavonoid hesperidin (Hesp) has emerged as promising anticancer natural product proved be potent antioxidant agent. ...
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