During the cultivation of Marsupenaeus japonicus, there are often obvious differences in growth within same family under food, water quality, and environment, which greatly affects efficiency. To explore molecular mechanism this difference, study used RNA-seq technology to compare transcriptomes M. japonicus individuals with significant from family. A total 1375 differentially expressed genes w...

The Chinese medicine Qigesan can be used to treat esophageal adenocarcinoma in the mainland widely, but its mechanism is unclear. In order investigate of treatment adenocarcinoma, concept network pharmacology was this study. database named TCMSP identify active therapeutic components as well targets Qigesan. TTD, OMIM, CTD, DrugBank, and GeneCards were genes related adenocarcinoma. STRING datab...

In this study, expressions of toll-like receptors (TLRs) and apoptosis-related genes in piglets and mitochondrial respiration in intestinal porcine epithelial cells were investigated after hydrogen peroxide (H2O2) exposure. The in vivo results showed that H2O2 influenced intestinal expressions of TLRs and apoptosis related genes. H2O2 treatment (5% and 10%) downregulated uncoupling protein 2 (U...


 Purpose: Breast cancer has over the years been one of major acute carcinomas in women. This study investigated fundamental mechanistic functions lncRNA-NEAT1/miR-148a-3p/Wnt/β-catenin axis moderating cell viability, apoptosis and autophagy Cancer (BC).
 Methods: RT-qPCR measured expression lncRNA NEAT1 microRNA-148a-3p human lines for Cancer. Cell transfection upregulated or silence...

Zerumbone (ZER), a natural compound has been extracted from Zingiber zerumbet with known pharmacological activities. The aim was to determine the anti-human Burkitt’s lymphoma (Raji) cell effect of ZER. 3-(4,5-dimethylthiazol-2-yl)-2,5,-diphenyltetrazolium bromide (MTT) assay used cytotoxic while Annexin-V-fluorescein isothiocyanate/propidium iodide-PI flow cytometric assays apoptotic ZER on hu...

In developed countries, contact with plastics is constant. Plastics contain a vast number of additives such as plasticisers, stabilisers, antioxidants, flame retardants, etc., that can impact human health. Most them have been studied separately; however, an integrative approach to identify genes, biological processes, molecular functions, and diseases linked exposure these compounds has not add...

Abstract The goal of this study was to demonstrate the functions and specific mechanism long non-coding RNA (lncRNA) GNAS-AS1 in lung adenocarcinoma. Levels lncRNA GNAS-AS1, microRNA (miR)-433-3p, Rab3A were assessed by quantitative real-time PCR (qRT-PCR). target-binding sites miR-433-3p, predicted confirmed bioinformatics tool (StarBase) a dual-luciferase reporter system. Cell proliferation a...

IntroductionPodocyte apoptosis is a common mechanism driving progression in Alport syndrome(AS). The aim of this study was to investigate the podocyte caused by COL4A3 mutations.MethodsWe recruited autosomal dominant AS(ADAS) patients. Patients with minimal change disease (MCD) were as controls. Microarray analysis carried out on isolated glomeruli from patients and validated. Then, correspondi...

Colorectal cancer, constitutes one of the most prevalent types cancer. Despite various treatment options, mortality rate is extremely high. Chemotherapy and/or radiotherapy might be beneficial for patients, however “indicators” which could predict response to above protocols, would helpful. Study circulating tumor cells (CTCs), in combination with high-sensitivity assays, contribute more succes...

In this study, it was aimed to investigate the antiproliferative and apoptotic effects of nivolumab, cetuximab gemcitabine used in treatment different cancer types as well cisplatin cyclophosphamide neuroblastoma on SH-SY5Y cells. The effect each chemotherapeutic cell viability individual IC50 values were determined by crystal violet method. To determine their effects, RT-PCR Annexin V-FITC apo...