VLDL cholesterol concentrations were determined in 1641 male and 608 female and VLDL apolipoprotein B concentrations in 505 male and 211 female company employees in Westphalia aged 17-70 years. VLDL cholesterol and VLDL apolipoprotein B values were found to be distributed with positive skew in both sexes but were higher in men than in women (median in men: VLDL cholesterol 0.30 mmol/l, VLDL apo...

BACKGROUND Although the link between hyperuricemia and metabolic syndrome had been recognized, the association of the dyslipidemia among individuals with hyperuricemia remains not comprehensively assessed. METHODS Using NHANES III study, we examined the relation between serum lipid profiles and different serum uric acid levels, including serum total cholesterol, LDL cholesterol, triglycerides...

Apolipoprotein mRNA Translation and PostTranslational Modification Co-translational processing of preapolipoproteins Post-translational processing of mammalian apolipoproteins a. ApoA-I b. ApoA-I1 Post-translational modification of apolipoproteins ApB-48 synthesis in the small intestine The Apolipoprotein Genes Chromosomal localization and linkage analysis a. ApoA-I/C -III/A-IV b. ApoE/C-I and ...

Apolipoprotein C-III deficiency provides cardiovascular protection, but apolipoprotein C-III is not known to be associated with human amyloidosis. Here we report a form of amyloidosis characterized by renal insufficiency caused by a new apolipoprotein C-III variant, D25V. Despite their uremic state, the D25V-carriers exhibit low triglyceride (TG) and apolipoprotein C-III levels, and low very-lo...

In this study, we examined the association between soy isoflavones and lipid profiles, apolipoprotein levels in patients with type 2 diabetes in China. The study population was composed of 120 cases (80 women with type 2 diabetes and 40 healthy women). Objects in treatment group received isoflavones 435 mg/day for 2 months, then lipid profiles were analyzed by the colorimetry method and apolipo...

The aim of the present study was to investigate the associations between total adiposity, body fat distribution, and plasma lipoprotein levels within groups of women defined on the basis of apolipoprotein E phenotypes, in order to verify whether apoE polymorphism could modify these associations. In women having only apolipoprotein E3 isoforms (n = 24), body fat mass, the waist: hip circumferenc...

Humans express a unique subset of high-density lipoproteins (HDLs) called trypanosome lytic factors (TLFs) that kill many Trypanosoma parasite species. The proteins apolipoprotein (apo) A-I, apoL-I, and haptoglobin-related protein, which are involved in TLF structure and function, were expressed through the introduction of transgenes in mice to explore their physiological roles in vivo. Transge...

coronary artery disease. We investigated the putative role of apolipoprotein E phenotypes in cerebral infarction. Methods: The apolipoprotein E phenotypes of 69 patients (mean±SD age, 72±+11 years) who had suffered completed stroke or a transient ischemic attack and 68 sexand age-matched control subjects free of cerebrovascular disease were determined by isoelectric focusing. The relative frequ...

A non-competitive sandwich enzyme-linked immunosorbent assay for apolipoprotein C-I was developed. Sheep antibody to this apolipoprotein C-I, purified by affinity chromatography, was used for coating the wells of a microtiter plate and as a conjugate with alkaline phosphatase. The linear range of the assay was from 80 ng to 15 ng. It was sensitive down to 5 ng. The intra-assay variation coeffic...

In a prospective epidemiologic study in company employees in Westfalia aimed at improving early diagnosis of coronary heart disease in 3069 men and 1387 women, concentrations of HDL-apolipoprotein A-I and HDL-cholesterol were measured and the results were correlated with several risk factors of coronary heart disease. A negative correlation between hypertriglyceridaemia and HDL-cholesterol (r =...