To examine the unproved hypothesis that dietary cholesterol affects the synthesis of apolipoprotein B and E, we fed rats a cholesterol-rich diet that has been shown to alter dramatically the serum concentrations of these apolipoproteins. Rats fed for 4 weeks on a cholesterol-rich diet accumulate increased concentrations of low Mr apolipoprotein B (+2.7-fold) and decreased concentrations of apol...

The 14 allele of the apolipoprotein E gene constitutes the major genetic risk factor to develop Alzheimer’s disease. If and how this protein contributes to the pathological cascade of Alzheimer’s disease is not known. The 14 allele particularly affects the cholinergic defect, which is one of the most consistent neurotransmitter problems in an Alzheimer’s disease brain. We have analysed several ...

apolipoprotein e (apo e) is a structural constituent of several serum lipoprotein classes. it plays an important role in lipid metabolism by acting as a ligand for low-density lipoprotein (ldl) and chylomicron remnant receptors. three common alleles called e2, e3 and e4 have been described, which code for three protein isoforms (e2, e3 and e4). the polymorphism is clinically significant, and it...