BACKGROUND Although dyslipoproteinemia is associated with arterial atherothrombosis, little is known about plasma lipoproteins in venous thrombosis patients. METHODS AND RESULTS We determined plasma lipoprotein subclass concentrations using nuclear magnetic resonance spectroscopy and antigenic levels of apolipoproteins AI and B in blood samples from 49 male venous thrombosis patients and matc...

BACKGROUND Although guidelines recommend measuring fasting lipids for initial screening of adults without cardiovascular disease (CVD), recent studies suggest that nonfasting triglycerides may be superior to fasting. Whether fasting status alters associations of nontriglyceride lipids with CVD is unclear. METHODS AND RESULTS In a prospective study of 26 330 healthy women (19 983 fasting; 6347...

Oxidation of low-density lipoprotein (LDL) may promote atherosclerosis, whereas the reverse transport oxidized lipids by high-density (HDL) contribute to atheroprotection. To provide insights into associations lipid oxidation markers with subclasses at population level, we investigated HDL (oxHDLlipids) and LDL (oxLDLlipids) in a population-based cross-sectional study 1395 Finnish adults ages 2...

Apolipoproteins are important constituents of lipoprotein particles and play a central role in the transport and metabolism of lipids (Goldstein et al., 1983). Different lipoproteins and apo have been identified. Recent epidemiological studies have shown the importance of the apolipoprotein B, and its direct correlation with the incidence of coronary heart disease (Sattar et al., 2004; Olofsson...

Eleven hybridoma antibodies specific for apoprotein B were used to examine the expression of apoprotein B epitopes on native plasma lipoproteins using fluid phase radioimmunoassays. Heterogeneity of apoprotein B in low density lipoprotein (LDL) of density 1.019-1.063 g/ml was indicated by maximum binding of radioiodinated LDL in the presence of excess antibody that ranged from 45 to 100%. Affin...

Over the past 10 years, many laboratories have investigated lipid metabolism and atherogenesis with a variety of transgenic and gene knockout mouse models. Although many of these studies have yielded valuable insights, some have been hampered by a paucity of useful antibodies against mouse proteins. For example, many laboratories have analyzed genetic and dietary interventions affecting lipopro...

169 oscopy, false positive results are not uncommon with double contrast radiology, and up to 29% of polyps may be missed, although this figure falls to under 10% for polyps over 1 cm in diameter.'3 The presence of diverticular disease makes the diagnosis of associated lesions more difficult,'0 14 some authorities recommending that colonoscopy should be performed in all patients with symptomati...

Apolipoprotein B obtained from each of the major density classes of human plasma lipoproteins was investigated immunochemically. Eleven different mouse hybridoma cell lines were generated and selected on the basis of their ability to secrete antibodies that were bound by either very low density or intermediate density lipoproteins. Two of these antibodies appeared to be specific for complex epi...