Running title: DiDonato et al.; Artery wall apoA1 is dysfunctional and not in HDL In In Inst st sti it itut te; e; ; 5 5 De Dept pt pt o of Cardiovascular Medicine, H H Hea a art and Vascul lar a a Ins nsti ti titu tute, Cleveland Clinic, D De Dept pt pt o o of f f Ch Ch Chem em emis is i t tr t y; 4 e De D pt o of f f Ma Math th them em e atic ic cs, s C C Cleve e ela a and Sta tate te e U U U...

Reverse cholesterol transport (RCT) is the pathway for removal of peripheral tissue cholesterol and involves transport of cholesterol back to liver for excretion, starting from cellular cholesterol efflux facilitated by lipid-free apolipoprotein A1 (ApoA1) or other lipidated high-density lipoprotein (HDL) particles within the interstitial space. Extracellular cholesterol then is picked up and t...

Synergism between gemfibrozil and CDD 3540, drugs used to elevate mouse serum HDL cholesterol and apoprotein A1, is modeled using nonlinear response surface techniques. This approach employs a common simple pharmacological model to describe the dose-response function. Its parameters are modeled as functions of drug mixture fractions using models borrowed from mixture experiment analysis methods...

CONTEXT Epidemiologically, levels of high-density lipoprotein (HDL) cholesterol and its major protein constituent, apolipoprotein A-I (apoA-I), are inversely related to risk of ischemic heart disease (IHD). OBJECTIVE We tested whether common genetic variation in the apolipoprotein A1 gene (APOA1) contributes to apoA-I and HDL cholesterol levels and risk of IHD in the general population. DES...

Cardiovascular complications have emerged as a major concern for cancer patients. Many chemotherapy agents are cardiotoxic and some appear to also alter lipid profiles, although the mechanism for this is unknown. We studied plasma lipid levels in 12 breast cancer patients throughout their chemotherapy. Patients received either four cycles of doxorubicin and cyclophosphamide followed by weekly p...

UNLABELLED A dietary supplement (AP, Armolipid Plus) that combines red yeast rice extract, policosanol, berberine, folic acid, coenzyme Q10 and asthaxantine can have beneficial effects on cardiovascular disease (CVD) biomarkers. The aim of this study was to assess whether the intake of AP, in combination with dietary recommendations, reduces serum low density lipoprotein cholesterol (LDL-c) con...

Background. Hypercholesterolemia and inflammation both contribute to the pathogenesis of atherosclerosis its clinical manifestations. Statins, possessing lipid-lowering anti-inflammatory properties, are currently recommended in all ischemic syndromes. Purpose. To compare effects atorvastatin rosuvastatin on lipid inflammatory markers patients with acute coronary syndromes (ACS). Methods. Two hu...

Abstract Background Neuropsychiatric manifestations occur in up to 75% of adult systemic lupus erythematosus (SLE) patients and are one the major causes death SLE patients. Cognitive dysfunction is a typical clinical feature neuropsychiatric (NPSLE), which seriously affects quality life Dyslipidaemia thyroid symptoms, prevalent patients, have both been related disturbances, including significan...

Background: Although clinical outcome of extranodal NK/T cell lymphoma (ENKTL) has been improved recently, some patients resistant to Asp-based chemotherapy suffered poorer survival. Therefore, reliable and convenient biomarkers become more important. Methods: We retrospectively analyzed 1017 ENKTL with available data between December 2003 August 2021. Demographics serum lipid 500 healthy contr...

  Abstract   Background: Recently, small dense low density lipoprotein (sdLDL) has been   highlighted as a new risk factor for the coronary artery disease (CAD).Small dense   LDLs are believed to be atherogenic since these particles are taken up more easily by   arterial wall. They are readily oxidized and have reduced affinity for low density   lipoprotein (LDL) receptor and increased affinity...