The neurochemistry of language and the neuropharmacology of aphasia are two domains of cognitive neuroscience still in their infancy. In this article we review what is known about these two domains, especially with regard to treating aphasia with drugs. Selected neurotransmitters can improve language function in certain patients with aphasia. We discuss which neurotransmitters work for which la...

Cortical reorganization in poststroke aphasia is not well understood. Few studies have investigated neural mechanisms underlying language recovery in severe aphasia patients, who are typically viewed as having a poor prognosis for language recovery. Although test-retest reliability is routinely demonstrated during collection of language data in single-subject aphasia research, this is rarely ex...

Purpose The purpose of this article is to review the behavioral treatments used in aphasia rehabilitation research that have been combined with transcranial direct current stimulation (tDCS). Although tDCS in aphasia treatment has shown promise, the results have not been conclusive, and their interpretation is further compounded by the heterogeneity of study characteristics. Because implementin...

One way to investigate the neuronal underpinnings of language competence is to correlate patholinguistic profiles of aphasic patients to corresponding lesion sites. Constituting the beginnings of aphasiology and neurolinguistics over a century ago, this approach has been revived and refined in the past decade by statistical approaches mapping continuous variables (providing metrics that are not...

Background: Within cognitive neuropsychological models, conduction aphasia has been conceptualized as a phonological buffer deficit. It may affect the output buffer, the input buffer, or both. The phonological output buffer is a short-term storage, responsible for the short-term maintenance of phonological units until their articulation, as well as for phonological and morphological composition...

An immediate generalization of the classical McKay correspondence for Gorenstein quotient spaces C/G in dimensions r ≥ 4 would primarily demand the existence of projective, crepant, full desingularizations. Since this is not always possible, it is natural to ask about special classes of such quotient spaces which would satisfy the above property. In this paper we give explicit necessary and suf...

We study linear actions of algebraic groups on smooth projective varieties X. A guiding goal for us is to understand the cohomology of “quotients” under such actions, by generalizing (from reductive to non-reductive group actions) existing methods involving Mumford’s geometric invariant theory (GIT). We concentrate on actions of unipotent groups H, and define sets of stable points X and semista...

Objectives: The purpose of this study was to investigate the differential performance on musical chord and grammaticality judgement tasks in post-stroke aphasia. accuracy task were analyzed, correlation between severity aphasia examined. Methods: Fourteen individuals with fifteen adults without participated study. subject listened a presented voice asked determine whether connection natural the...

Patients with the semantic variant of primary progressive aphasia, also known as semantic dementia, and Alzheimer's disease have deficits in semantic memory. However, few comparative studies have been performed to determine whether these patient groups have distinct semantic memory impairments. We asked 15 patients with semantic variant primary progressive aphasia and 57 patients with Alzheimer...

In this paper, we consider quotient structure and quotient difunctions in the context of interior and closure operators on textures in the sense of Dikranjan-Giuli. The generalizations of several results concerning separation and quotient mapping are presented. It is shown that the category of interior-closure spaces and bicontinuous difunctions has a T0 reflection. Finally, we introduce some c...