results overall suicide mortality has increased from 10.6 per 100,000 in 2003 to 12.4 in 2014, which equals to 1.5 % (+0.1 - + 2.8) annual percentage change (apc). increase in suicide rate for women was remarkably higher than men (apc = 4.5 for women and 0.5 for men (p value < 0.001)). majority of increase belonged to age group 20 - 29 in women and 30-39 in men. old men have an increasing trend...

Inactivation of membrane-bound factor Va by activated protein C (APC) proceeds via a biphasic reaction that consists of a rapid and a slow phase, which are associated with cleavages at Arg506 and Arg306 of the heavy chain of factor Va, respectively. We have investigated the effects of protein S and factor Xa on APC-catalyzed factor Va inactivation. Protein S accelerates factor Va inactivation b...

Test for the evaluation of the overall coagulation potential in plasma. Given the central role of thrombin in blood clotting, the tendency of a plasma sample to generate thrombin might contain useful information about thrombotic or haemorrhagic risk. In this presentation I will talk about the thrombin generation (TG) assay by the Calibrated Automated Thrombogram (CAT), developed in Maastricht b...

The generation of thrombin by the prothrombinase complex constitutes an essential step in hemostasis, with thrombin being crucial for the amplification of blood coagulation, fibrin formation, and platelet activation. In the prothrombinase complex, the activated form of coagulation factor V (FVa) is an essential cofactor to the enzyme-activated factor X (FXa), FXa being virtually ineffective in ...

The aim of this study was to examine the occurrence of venous thromboembolism (VTE) in relation to factor V-related risk factors. Using a nested case-control design combining 2 population-based prospective studies, we measured factor V Leiden, HR2 haplotype, activated protein C (APC) resistance, and plasma factor V antigen in 335 participants who developed VTE during 8 years of follow-up and 68...

Clotting factor V has a dual function in coagulation: after activation, procoagulant factor V stimulates the formation of thrombin, whereas anticoagulant factor V acts as a cofactor for activated protein C (APC) in the degradation of factor VIII/VIIIa, thereby reducing thrombin formation. In the present study, we evaluated whether plasma factor V levels, either decreased or increased, are assoc...