MAb directed to the thyroid microsomal antigen have been developed. All bound to 101- and 107-kD bands in Western blot analysis using thyroid microsomal fraction as antigen. The MAb also bound to microsomal proteins immunoprecipitated by serum from patients having a high titer of anti-microsomal antibody but no antibodies to thyroglobulin or thyrotropin-stimulating hormone receptor. The pattern...

O BJECTIVE: The goal of this study was to modify and optimize the screening and diagnostic procedures of unexplained recurrent abortion. Antithyroid antibodies, parvovirus B19 (B19V) and cytomegalovirus (CMV) infections, which were usually overlooked in clinical practice of handling cases of recurrent abortion, were studied to evaluate their role in the pathogenesis of recurrent first trimester...

Background: Hypothyroidism was the diagnosed and treated as a result of health related quality life issues. The aim this study that to evaluate effect IL-36 γ, Tg-Ab TOP-Ab in Hashimoto’s Thyroiditis (HT). Study design: This cross sectional conducted at Rawal Institute sciences, Islamabad duration six month, from April 2022 September 2022. Methods: A total number patients n=150 which divided in...

background: infections attributed to helicobacter pylori ( h. pylori ) involve almost half of the world's population. one of the effects is auto-antibody induction and cross-reaction with numerous proteins in the body. as a result of its widespread prevalence and importance, this study evaluates the associations between h. pylori and thyroid auto-antibodies. materials and methods: this study en...

Dyshormonogenesis is an uncommon cause of congenital hypothyroidism. The most common abnormality is absent or insufficient thyroid peroxidase enzyme. Maternal intake of antithyroid drug can also lead to elevated thyroid stimulating hormone (TSH) in a neonate, albeit the scenario is temporary. We report one such interesting case where a clinically euthyroid neonate borne to a mother on antithyro...

Background Approximately 2-4% of all women have recurrent spontaneous abortion (RSA); however, the cause is determined in only 50% of cases. Recent studies have shown an association between thyroid autoantibodies as a sign of thyroid autoimmunity and abortion. The aim of the present study was to determine whether circulating anti-thyroid peroxidase (anti-TPO) was associated with RSA. MaterialsA...

Iodination of the isolated thyroglobulin (Tg) by peroxidase was compared with various Tg preparations obtained from patients with thyroid diseases. For the purpose, the iodination process was observed in the incubation medium containing Tg, iodide, H2O2-generating system, and thyroid peroxidase (TPO) or lactoperoxidase (LPO). During the incubation, iodination of Tg preparations increased gradua...

conclusions thyroid dysfunction was not higher in sle patients compared to healthy individuals. however, anti-tg antibodies were higher in sle patients. it has not yet been established that thyroid function tests should be performed routinely in sle patients. results the mean age of sle patients and controls were 32.16 ± 9.19 and 32.48 ± 9.47 years, respectively (p = 0.821). patients had signif...

The in vivo effect of thyrotropin (TSH) on the intracellular localization of thyroid peroxidase (TPO) in rat thyroid epithelial cells was examined by an indirect immunofluorescence method. The staining for TPO in the epithelial cells of normal rats appeared all over the cytoplasm, especially in the apical region. The injection of propylthiouracil for 3-10 days increased the staining in the apic...