Whether fever represents a beneficial or harmful response to infection has been debated for hundreds of years. The issue is clouded by a common misunderstanding that fever is the reason an individual with infection feels ill: often once the elevated body temperature abates, the patient feels better. It is assumed therefore that reducing the fever would improve the patient’s condition and shorte...

When infused into the lateral cerebral ventricles of rabbits, human endogenous pyrogen (EP) preparations induced dose-dependent increases in slow-wave sleep concomitant with increasing body temperature. Heating EP to 70 degrees C destroyed its sleep-promoting and pyrogenic activity. Anisomycin (an antipyretic) prevented EP from increasing body temperature without affecting its sleep-promoting a...

Rats have an attenuated febrile response to intravenous endogenous pyrogen [e.g., interleukin-1β (IL-1β)] near the term of pregnancy. The present experiments were carried out on 25 nonpregnant and 32 pregnant rats to test the hypothesis that arginine vasopressin functioning as an endogenous antipyretic substance in the central nervous system mediates this attenuated febrile response. An intrave...

To examine whether antipyretic therapy in young children is associated with potential risks (interference with enhanced host defences at febrile temperatures) or benefits (improved comfort and behaviour), a randomised, double-blind, placebo-controlled trial of paracetamol was conducted among 225 children 6 months to 6 years of age who presented with acute (less than or equal to 4 days) fever (g...

We report the treatment of a rare case central hyperthermia due to intracerebral hemorrhage (ICH) in basal ganglia with baclofen. Central is associated high mortality rate and poor prognosis among patients failure thermoregulation system. A 35-year-old man arrived at emergency room sudden loss consciousness right-sided hemiparesis. Computed tomography revealed an ICH left midline shift. Followi...

Abstract Tardigrades in their natural environment are exposed to various environmental toxicants, including non-steroidal anti-inflammatory drugs (NSAIDs) or antipyretics such as paracetamol. This drug can enter the animal’s body through wall digestive system with food and affect biology of organisms. In this paper, we report for first time effects paracetamol on tardigrade storage cells. We an...

Fever is a common occurrence in adults and children in community and healthcare settings. Despite this, it does not seem to be common knowledge that fever is a natural response to an invading organism and that most fevers are associated with self-limiting viral illnesses.1–3 Many health professionals and the general public see fever as an illness in itself not as a highly coordinated protective...

A 2 1/2-year-old female presented to the Department of Paediatrics with a fever (38.2 degrees C) and bilateral swelling of the parotid salivary glands. A month later, she presented with similar signs and symptoms. Three months later the patient had a third attack and was referred to the Paediatric Dental Department. A clinical examination and sialography showed a normal Stensen's duct. The pare...