An aqueous extracts of stem and leaves of Boerhaavia Diffusa (Aq.EBD) and leaves of Anisochilus Carnosus (Aq.EAC) was studied for hepatoprotective, analgesic and antipyretic activity. Hepatotoxicity was introduced in Albino rats of either sex by intraperitoneal injection of CCl4 (in olive oil). Tail immersion method and Hot plate method in mice were studied for analgesic activity, Yeast induced...

Arginine vasotocin (AVT) is a nonmammalian analog of the mammalian hormone arginine vasopressin (AVP). These peptides are known for their antidiuretic and pressor effects. More recently, AVP has been recognized as an important antipyretic molecule in mammals. However, no information exists about the role of AVT in febrile ectotherms. We tested the hypothesis that AVT is an antipyretic molecule ...

The department of internal medicine at the University of Strassburg in the 1880s was noted for its investigations into intestinal worms. Adolf Kussmaul, the director, asked two young assistants, Arnold Cahn and Paul Hepp, to treat patients with naphthalene as it had been used elsewhere as an internal antiseptic. The young doctors were disappointed with the initial results, but Hepp persevered w...

Purpose: The aqueous fruit pulp extract of Hunteria umbellata K. Schum is used traditionally for the treatment of various fevers. The purpose of this study was to evaluate the extract for antipyretic and analgesic activity, and determine its probable mechanism of action. Methods: Pyrexia was induced in rabbits by intravenous injection of 10 5 CFU of E. coli/kg. Rectal temperature was monitored ...

An aqueous extracts of stem and leaves of Boerhaavia Diffusa (Aq.EBD) and leaves of Anisochilus Carnosus (Aq.EAC) was studied for hepatoprotective, analgesic and antipyretic activity. Hepatotoxicity was introduced in Albino rats of either sex by intraperitoneal injection of CCl4 (in olive oil). Tail immersion method and Hot plate method in mice were studied for analgesic activity, Yeast induced...

Shorea robusta Gaertn. f. (Sal) is one of the most important traditional Indian medicinal plants. The resin of the plant has been used in the treatment of inflammation in folklore medicine. In the present study, ethanolic extract (70%) of S. robusta resin (SRE) was investigated for its anti-inflammatory and antipyretic activities. Acute inflammation was produced by carrageenan-induced hind paw ...

The aqueous extract of Parsley ( Petroselinum crispum ) were investigated for anti-inflammatory, analgesic and antipyretic activity at the doses of 2 , 5 , and 10 g/kg, of body weight. The experimental paradigms used were carrageenan, dextran, histamine induced pedal edema and cotton pellet induced granuloma for anti-inflammatory activity, while hot plate and acetic acid induced writhing method...

Although salicylates are widely used as antipyretic agents, the mechanism by which they lower body temperature is controversial. It has been suggested that these compounds act at peripheral sites of inflammation, by suppressing release of endogenous pyrogen from leucocytes exposed to an inflammatory stimulus (1), or by suppressing synthesis and release of fever-inducing prostaglandins (2, 3). A...

The present study was designed to investigate the gastroprotective, analgesic, and antipyretic effects of curcumin (Cur), the major constituent of turmeric. Acetylsalicylic acid (ASA) was used in this study as a standard drug for comparison. The analgesic activity was measured using the Hot-Plate Test. The antipyretic and antiulcer effects were assessed using yeast-induced pyrexia and gastric u...

A novel series of 2-(substituted phenoxy)-N-(1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)acetamide and N-(2-bromocyclohexyl)-2-(substituted phenoxy)acetamide derivatives having cyclohexyl nucleus as common in both types were synthesized and assessed for their antiinflammatory activity by a carrageenan induced rat paw oedema method, analgesic activity by Eddy’s hot plate method and antipyretic acti...