Generalised pruritus occurs in 25-50/ of cases of polycythaemia vera. Neither the cause nor the most effective treatment has been established. A relation with iron deficiency has been suggested and relief after iron treatment recorded.' Cholestyramine has been reported to have an antipruritic action in polycythaemia vera, which might imply an association with raised concentrations of conjugated...

BACKGROUND Canine flea-allergy dermatitis (FAD), a hypersensitivity response to antigenic material in the saliva of feeding fleas, occurs worldwide and remains a common presentation in companion animal veterinary practice despite widespread availability of effective systemic and topical flea-control products. HYPOTHESIS/OBJECTIVES To evaluate the clinical response in dogs with FAD treated top...

Interleukin (IL)-31 is a key cytokine that contributes to pruritus in atopic dermatitis (AD). Recently, the treatment with anti-IL-31 receptor alpha (RA) antibody exhibited remarkable antipruritic effect AD patients. In clinical trial, serum levels of thymus activation-regulated chemokine (TARC), biomarker AD, were unexpectedly increased some patients treated anti-IL-31RA antibodies, without an...

Menthol is a naturally occurring monoterpene alcohol possessing remarkable biological properties including antipruritic, analgesic, antiseptic, anti-inflammatory and cooling effects. Here, we examined the menthol-evoked Ca2+ signals in breast and prostate cancer cell lines. The effect of menthol (50-500µM) was predicted to be mediated by the transient receptor potential ion channel melastatin s...

Reverse osmosis (RO) concentrate from wastewater reuse facilities contains concentrated emerging pollutants, such as pharmaceuticals. In this research, a paper-like composite sheet consisting of titanium dioxide (TiO2) and zeolite was synthesized, and removal of the antipruritic agent crotamiton from RO concentrate was studied using the TiO2/zeolite composite sheet. The RO concentrate was obtai...

Case report We present three cases of previously healthy adult patients diagnosed with varicella in December 2012 with uncommon onsets, but with mild evolution of the disease. Patient 1: female, age 45, had an atypical onset with very few vesicles only one on the trunk, and then on the head after five days, but with inflammatory occipital lymph nodes. From day 6, our patient had typical dermato...

Post-burn pruritus is a common and distressing sequela of burn scars. Empirical antipruritic treatments usually fail to have a satisfactory outcome because of their limited selectivity and possible side effects. Therefore, novel drug targets need to be identified. Here, we aimed to investigate the possible role of protease-activated receptor 2 (PAR2) and transient receptor potential vanniloid 3...

The three antihistaminic drugs investigated are of diverse chemical types, and many chemical methods have been reported for their assay. Cyproheptadine hydrochloride (CPH) is a serotonin and a histamine antagonist with anticholinergic and sedative effects. It also blocks voltage sensitive calcium channels in pancreatic islet cells and smooth muscle. CPH is also used as an appetite stimulant to ...

Recently, we showed that a methanol extract of Ganoderma lucidum inhibits scratching, an itch-related response, induced by intradermal injections of some pruritogens in mice. The present study investigated whether G. lucidum extract would inhibit allergic itch. In mice sensitized with an extract of salivary gland of mosquito (ESGM), an intradermal injection of ESGM elicited scratching, which wa...