Mangroves are enriched with various bioactive compounds is an inevitable fact. Almost all the mangroves exhibited good biological activities against human, animal and plant pathogens. In this study, mangrove Avicennia marina screened Plasmodium falciparum. (Forsk)Vierh. evergreen tree found along tropical subtropical coastlines. It well known for being antibacterial, anticancer, antioxidant, an...

Abstract Five known compounds (1–5) were isolated from the extract of Mundulea sericea leaves. Similar investigation roots this plant afforded an additional three (6–8). The structures elucidated using NMR spectroscopic and mass spectrometric analyses. absolute configuration 1 was established ECD spectroscopy. In antiplasmodial activity assay, compound showed good with IC50 2.0 μM against chlor...

A library of enriched marine natural product fractions was screened for their antiplasmodial activity using a SYBR green I fluorescence-based assay. Fractions derived from a sponge of the genus Spongosorites exhibited potent inhibition of Plasmodium falciparum growth. This genus of sponge has been reported to contain the nortopsentin and topsentin class of bis-indole imidazole alkaloids. This i...

Background: Despite the various medicinal applications of Schumanniophyton magnificum, no comparative data are available to determine part with best antiplasmodial activity and guarantee its safety. This work deals evaluation methanolic extracts S. magnificum organs as well study acute toxicity most active part.
 Materials methods: The leaves, stem bark, trunk wood, root wood were obtained...

Fourteen plant species collected in Iran and selected mainly on the basis of their antimicrobial and/or antifungal activities were evaluated for in vitro antiplasmodial and cytotoxic effects in a study designed to screen plant extracts with selective activity against Plasmodium falciparum. The methanol extracts of nine of the species tested exhibit activity against Plasmodium falciparum (MIC va...

malaria is a major international public health problem. drug-resistant parasites have made treatment and control of malaria more difficult. therefore, safe, affordable and effective new drugs are urgently needed. traditional medicine is an important source for new drugs. determining the ancient medicinal books was the first step of this study for finding malaria or disease that has symptoms lik...

In the course of our search for antimalarial leads from marine algae, four metabolites, sargaquinoic acid, sargahydroquinoic acid, sargaquinal and fucoxanthin, were isolated from the South African alga Sargassum heterophyllum. Fucoxanthin and sargaquinal showed good antiplasmodial activity toward a chloroquine-sensitive strain (D10) of Plasmodium falciparum (IC50 1.5 and 2.0 microM, respectivel...

wALADin1 benzimidazoles are specific inhibitors of δ-aminolevulinic acid dehydratase from Wolbachia endobacteria of filarial nematodes. We report that wALADin1 and two derivatives killed blood stage Plasmodium falciparum in vitro (50% inhibitory concentrations, 39, 7.7, and 12.8 μM, respectively). One of these derivatives inhibited gliding motility of Plasmodium berghei ANKA infectious sporozoi...

From the root bark of Erythrina abyssinica a new pterocarpene [3-hydroxy-9-methoxy-10-(3,3-dimethylallyl)pterocarpene] and a new isoflav-3-ene [7,4'-dihydroxy-2',5'-dimethoxyisoflav-3-ene] were isolated. In addition, the known compounds erycristagallin, licoagrochalcone A, octacosyl ferulate and triacontyl 4-hydroxycinnamate were identified. The structures were determined on the basis of spectr...