Antiphospholipid syndrome is an autoimmune disorder characterized by arterial or venous thrombosis, recurrent first-trimester pregnancy loss, and multiple additional clinical manifestations. We describe a man with severe atherosclerotic basilar artery stenosis and superimposed in situ thrombus who was found to have antiphospholipid syndrome.

Reducing the risk of hypertensive disorders of pregnancy Recommend women at high risk for preeclampsia (such as previous preeclampsia from before 34-36 weeks) to take 75 mg oral aspirin daily from 12 weeks to birth of the baby. Women with SLE (systemic lupus erythematosus) or antiphospholipid antobodies or antiphospholipid syndrome are recommended low molecular weight heparin in addtion (see re...

Thyroid disorders are commonly associated with coagulopathy. Patients with hyperthyroidism have increased risk for developing thromboembolic accidents, which are favoured by a simultaneous presence of antiphospholipid antibodies syndrome. in this paper, we describe the case of a patient with Graves' disease, who developed strokes with antiphospholipid antibodies syndrome.

A 32-year-old woman had a recurrent shallow ulcer on the flank. A biopsy specimen showed thromboses in the dermal vessels and she was found to have circulating antiphospholipid antibody with no associated systemic disease. A clean ulcer developed on the flank of a patient with primary antiphospholipid syndrome is considered to be a rarely encountered/unusual presentation of this syndrome.

This case presents a young patient with myocardial infarction, in-situ thrombosis of left anterior descending coronary artery and right common-iliac artery due to primary antiphospholipid syndrome. This report discusses the relationship between antiphospholipid antibodies and coronary artery disease along with management of this rare condition.

Key content: • The diagnosis of antiphospholipid syndrome (APS) requires both characteristic clinical features and persistently abnormal laboratory tests. • Antiphospholipid syndrome can cause serious morbidity in mother and fetus. • Good management in an expert setting can result in a live birth rate of 80%. • Prepregnancy assessment and counselling play an important part in optimising the cha...

Thromb Haemost 2006; 95: 900–1 Hyperhomocysteinaemia is a risk factor for thrombosis and recurrent pregnancy loss (1–2). Similar mechanisms appear to mediate thrombosis and pregnancy loss associated with hyperhomocysteinaemia and with antiphospholipid antibodies (3). We report the case of a female patient with an unusual association of hyperhomocysteinemia, normocalcemic hyperparathyroidism, gr...

Objective: Studies on antiphospholipid antibodies have mainly focused on the IgG and IgM isotypes, with only a few investigating the pathogenic significance of IgA antiphospholipid antibodies. Positive IgA anticardiolipin (aCL) and IgA anti-β2 glycoprotein I (anti-β2GPI) were reported to be predominantly associated with other antiphospholipid antibodies, making it difficult to understand the ro...

We present the first reported case of antiphospholipid syndrome with stroke in an Iranian boy (7-month-old) who had two ischemic strokes within a period of 2 months. Serum anticardiolipid antibody was positive and the patient had low levels of protein S and C. This case emphasizes the importance of antiphospholipid antibody in children with unexplained ischemic stroke.