Atherosclerosis, the underlying cause of heart attack and stroke, appears to be an inflammatory disease driven by retention of modified lipoproteins in the artery wall.1 Markers of inflammation, such as high sensitivity C-reactive protein, are independent predictors of cardiovascular (CV) events.2 If atherosclerosis truly is an inflammatory disease, then shouldn’t we be able to identify antiinf...

Juvenile idiopathic arthritis (JIA) is an umbrella term for seven or more clinical patterns of arthritis of unknown cause in children. Until the mid-1980s, therapy for children, with what was then called juvenile rheumatoid arthritis in the United States and juvenile chronic arthritis (JRA) elsewhere, consisted primarily of a small repertoire of antiinflammatory drugs and corticosteroids. Howev...

REFERENCES 1. Szczeklik A. Adverse reactions to aspirin and nonsteroidal antiinflammatory drugs. Ann Allergy 1987;59:113-18. 2. Alkhawajah AM, Eifawai M, Mahmoud SF Fatal anaphyiactic reaction to diclofenac. Forensic Sci Int 1993;60:107-10. 3. Mescheder A, Nokhodian A, Kirch W. Anaphylactic shock as complication of Ml application of diclofenac. Arzneimitteltherapie 1993;11:237-9. 4. Romano A, P...

Prostate cancer is often slowly progressive, and it can be difficult to treat with conventional cytotoxic drugs. Nonsteroidal antiinflammatory drugs inhibit the development of prostate cancer, but the mechanism of chemoprevention is unknown. Here, we show that the R-enantiomer of the nonsteroidal antiinflammatory drug etodolac inhibited tumor development and metastasis in the transgenic mouse a...

The discovery of inducible cyclooxygenase-2 enzyme led to the development of a new generation of nonsteroidal antiinflammatory drugs, most commonly known as coxibs. Within a short span of time, coxibs became the most widely prescribed drugs (with annual sale of more than $5 billion in the US) due to their gastroprotective effect. But immediate and voluntarily withdrawal of rofecoxib due to exce...