نتایج جستجو برای: antihistamine decongestant
تعداد نتایج: 1454 فیلتر نتایج به سال:
The purpose of this study was to evaluate changes in nasal resistance to ajrflow in persons undergoing rapid maxillary expansion and to reevaluate the responses at a l-year follow-up. Nasal resistance measurements, assessed in four modes (natural state, anterior nares dilation with Tygon tubing, following administration of decongestant, and nares dilation with tubing and decongestant), were tak...
Nasal congestion is one of the most troublesome symptoms of many upper airways diseases. We characterized the effect of selective a2c-adrenergic agonists in animal models of nasal congestion. In porcine mucosa tissue, compound A and compound B contracted nasal veins with only modest effects on arteries. In in vivo experiments, we examined the nasal decongestant dose-response characteristics, ph...
synthesis and anti-inflammatory performance of newly cyclizine derivatives on adult male wistar rats
cyclizine (1-benzhydryl-4-methyl-piperazine, cas 82-92-8, cyc, i), a piperazine derivative, belongs to h1 antihistamine group of drugs that shows such pharmacological properties as anti-inflammatory, anti-allergic and anti-platelet effects, similar to other h1-receptor antagonists. in this study, two new tolyl and cumene derivatives of i (1-ethyl-4-[(p-isopropylphenyl) (p-tolyl) methyl]-piperaz...
This paper presents a method for the determination of phenylephrine hydrochloride in pharmaceuticals by spectrophotometric flow injection analysis exploiting the reaction with potassium ferricyanide and 4-aminoantipyrine, which leads to the formation of a condensation product with strong absorptivity at 500 nm. The linear dynamic range was between 0.95 and 9 mg/L, with a limit of detection of 0...
Aim of the study was to evaluate the effect of a 2-year course of subcutaneous specific immunotherapy or continuous oral antihistamine treatment on the eosinophilic inflammation in nasal secretions of patients with severe persistent allergic rhinitis caused by house dust-mites. After informed consent, 31 rhinitis patients, sensitive to dust-mite antigens, were enrolled: 12 were randomly assigne...
The structure of a major active metabolite of the nonsedating antihistamine loratadine was confirmed by synthesis. The metabolite 3 was prepared from 3-methyl pyridine in twelve steps.
Compounds a containing bicyclo[1.1.1]pentane (BCP) adjacent to chiral center can be prepared with high enantiomeric excess through asymmetric transfer hydrogenation (ATH) of ketones. In the reduction step, BCP occupies position distant from η6-arene catalyst. The was applied synthesis analogue antihistamine drug neobenodine.
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