Drug resistance poses a significant challenge in antifungal therapy since resistance has been found for all known classes of antifungal drugs. The discovery of compounds that can act synergistically with antifungal drugs is an important strategy to overcome resistance. For such combination therapies to be effective, it is critical to understand the molecular basis for the synergism by examining...

We investigated the antifungal effect of dihydrodehydrodiconiferyl alcohol 9'-O-β-D-glucoside (DDDC9G) and its mechanism(s). Antifungal susceptibility testing showed that DDDC9G exhibted potent antifungal activities with almost no hemolytic effect. To understand the antifungal mechanism(s) of DDDC9G, we conducted the following experiments in this study using Candida albicans. Fluorescence exper...

Nanoparticles (NPs) have great potential for use in the fields of biomedicine, building materials, and environmental protection because of their antibacterial properties. However, there are few reports regarding the antifungal activities of NPs on plants. In this study, we evaluated the antifungal roles of NPs against Botrytis cinerea, which is a notorious worldwide fungal pathogen. Three commo...

abstract objective: shallots are important part of the diet for many people and there is long-held belief in their health enhancing properties. the aim of this study was to determine antifungal activity of shallot against reference fungal strains. methods: alcoholic and aqueous extracts of shallot (allium hirtifolium) were tested for in vitro antifungal activities against aspergillus fumigatus,...

Dear Readers, Denture-induced stomatitis is the most common type of oral candidosis and the most frequent mucosal alteration associated with complete or removable partial dentures in the elderly. Despite being an infection of multifactorial etiology, this condition has as main etiological factor the colonization of denture-bearing mucosa and acrylic bases by species of Candida spp., especially ...

In the present work we report the antifungal and cytotoxic activities of a neolignan 8.O.4 ́series. The most active antifungal compounds show a significant cytotoxic effect which might be related. Introduction Fungal infections have emerged during the past two decades as important pathogens causing morbidity and mortality in an increasingly diverse and progressively expanding populations of inmu...

Background: Pistacia khinjuk is one of the three species Pistacia growing in Iran. The essential oils of some Pistacia plants contain variety of components with different therapeutical effects. Objective: The purpose of this study was to provide the examination of antibacterial and antifungal effects of chloroform, ethyl acetate, ethyl alcohol and diethyl ether extracts obtained from the leaves...

Objective(s): The application of synthetic antimicrobial and antifungal compounds is reducing in the last decades in the food and nutrition fields owing to their various side effects and increasing interest of consumers to eat natural foodstuffs without artificial constituents. Clove (Syzygium aromaticum) has numerous medicinal properties, including analgesic, antiseptic, stimulants, carminativ...

Abstract: Despite several topical and systemic antifungal drugs are used for the treatment of fungal infection, Amphotericin B (AmB) is still one of the most common first-line choices in systemic fungal infection for over seventh decades from discovery. Amphotericin B which is belonged to the polyene group has a wide spectrum in vitro and in vivo antifungal activity. Its mechanism of antifunga...