The effect of petroleum ether (60-80 C), ethanol and aqueous extracts of Datura stramonium Linn. leaves on the estrous cycle were studied and identify the estrogenic activity of active ethanol extract in female albino rats. After the oral acute toxicity study, plant extracts were administered at two dose levels: 200 and 400 mg/kg, respectively. Ethanol extract at a dose of 200 mg/kg has increas...

OBJECTIVE The objective of this study was to evaluate the potential antifertility activity of feeding diets containing 30% fenugreek seeds to male and female white New Zealand rabbits. RESULTS The data presented in this study clearly demonstrate an antifertility effect of fenugreek seeds in the female rabbits and more of a toxicity effect in the male rabbits. In males, testis weight was reduc...

Carica papaya Linn. is commonly called as paw-paw and it belongs to the family Caricaceae. Papaya possess excellent medicinal properties for treatment of different ailments. The different parts of the Carica papaya plant including leaves, seeds, latex and fruit exhibited to have medicinal value. The stem, leaf and fruit of papaya contain plenty of latex. The latex from unripe papaya fruit conta...

The mouse zona pellucida glycoprotein, mZP2, is thought to be the secondary receptor on eggs for retention of acrosome-reacted sperm during fertilization. Here, we present evidence that one of its complementary binding proteins on sperm is proacrosin/acrosin. mZP2 binds to proacrosin null sperm considerably less effectively than to wild-type sperm. Binding is mediated by a strong ionic interact...

The postcoital antifertility activity of a series of triarylalkenes and triarylalkanols with basic ether groups has been examined in mice and rats. The triarylalkenes were, in general, more potent than the others, and more potent orally than by injection. Apart from having a greater sensitivity than the mouse, the rat appears to give essentially the same information about relative potency and o...

Fertility control is an issue of global and national public health concern. Many studies have been done on the male contraception. The traditional use of medicinal plants to treat different sorts of diseases, including fertility related problems is widespread throughout the world as many plant substances are known for their interferences with the male reproductive system. The present review is ...