Methanol is responsible for a life-threatening poisoning. Fomepizole, a potent alcohol dehydrogenase inhibitor, is an efficient and safe antidote that prevents or reduces toxic methanol metabolism. Although no study has compared its efficacy with ethanol, fomepizole is recommended as a first-line antidote. Treatment should be started as soon as possible, based on history and initial findings in...

Bleeding is a rare complication of direct oral anticoagulant potentially associated with high mortality rates. Biological monitoring is necessary for more than 24 h after idarucizumab antidote therapy in case of bleeding with dabigatran therapy.

This paper considers the role of space in overcoming knowledge stickiness discussing space as both a location and a gap between other things. Qualitative case data indicates that there are three areas of space that need to be considered; physical, mental and virtual, as well as a range of reasons why space alone is not enough to support knowledge creation and learning. We argue that recognising...

Purpose: To utilise DIcipher, an escape-room challenge, to provide a simulation of using drug information (DI) skills answer questions in the medical (MI) department within pharmaceutical industry. Methods: The 15-minute challenge required groups solve one clue and retrieve DI about iron deficiency anaemia. resources were used search for answers unlock box with antidote. A debriefing session fo...

This important new series will provide definitive and authoritative guidance on the use of antidotes to treat poisoning. The International Programme on Chemical Safety (IPCS) and the Commission of the European Communities (CEC) (ILO/UNEP/WHO) have jointly undertaken a major programme to evaluate antidotes used clinically in the treatment of poisoning. The aim of this programme has been to ident...

Heparin has been the most commonly used anticoagulant drug for nearly a century. The drug heparin is generally categorized into three forms according to its molecular weight: unfractionated (UF, average molecular weight 13 000), low molecular weight (average molecular weight 5000) and ultra-low-molecular-weight heparin (ULMWH, average molecular weight 2000). An overdose of heparin may lead to v...