Diabetes mellitus is the most common metabolic disorder affecting millions worldwide. It is recognized as a global major health problem. As alternatives to the available orthodox medicines, plants are considered a potential source for the treatment of diabetes within traditional ethnomedicine practices. In the Jordanian traditional medicine a significant selection of ethnobotanicals is promoted...

There is an urgent medical need for orally effective drugs to replace insulin injections for the treatment of diabetes mellitus. Vanadium complexes with insulin-mimetic activities have recently been proposed as candidates as new antidiabetic drugs. Following in vitro and in vivo studies on a group of bis(3-hydroxy-4-pyronato)oxovanadium(IV) (1) complexes with VO(O4) coordination mode, bis(allix...

Diabetes mellitus (DM) is a chronic endocrine disease resulted from insulin secretory defect or insulin resistance and it is a leading cause of death around the world. The care of DM patients consumes a huge budget due to the high frequency of consultations and long hospitalizations, making DM a serious threat to both human health and global economies. Tea contains abundant polyphenols and caff...

BACKGROUND Strychnos nux-vomica, commonly known as kuchla, contains strychnine and brucine as main constituents. Minor alkaloids present in the seeds are protostrychnine, vomicine, n-oxystrychnine, pseudostrychnine, isostrychnine, chlorogenic acid, and a glycoside. Seeds are used traditionally to treat diabetes, asthma, aphrodisiac and to improve appetite. OBJECTIVE The present study was aime...

In vitro antidiabetic effect of fruits and vegetables with reports as folk remedies were investigated. The antidiabetic effects were evaluated by comparing the inhibitory properties of α-glycosidase, aldose reductase, and antioxidant activity. The results indicated that lychee extract exhibited the best dose-dependent inhibitory activity against α-glycosidase with IC 50 of 10.4 mg/mL, and lemon...

The genus, Salacia belongs to the family, Celastraceae and is distributed across the world. Roots and stems of Salacia are used mainly as antidiabetic agents in traditional system of medicine such as Ayurveda and Unani. The roots are either chewed directly or taken in dried powdered form or as decoction. Apart from antidiabetic activity, several species of the genus Salacia are known to possess...

The antidiabetic and antioxidant activities of the ethyl acetate-soluble extract (MFE) of mulberry fruit (Morus alba L.) were investigated. In vitro, MFE showed potent α-glucosidase inhibitory activity and radical-scavenging activities against DPPH and superoxide anion radicals. In vivo, MFE could significantly decrease fasting blood glucose (FBG) and glycosylated serum protein (GSP), and incre...

Diabetes mellitus is the most common metabolic disorder affecting millions worldwide. It is recognized as a global major health problem. As alternatives to the available orthodox medicines, plants are considered a potential source for the treatment of diabetes within traditional ethnomedicine practices. In the Jordanian traditional medicine a significant selection of ethnobotanicals is promoted...

Diabetes mellitus type 2 is a metabolic disorder characterized by hyperglycemia including insulin resistance and relative lack of insulin. Type 2 diabetes is expected to reduce ten-year-shorter life expectancy. In this research article, we have isolated two terpenoids from the stem bark of Syzygium alternifoliumby column chromatography.The isolated compounds were identified as friedelin and 3β-...

Article history: Received on: 26/01/2013 Revised on: 19/02/2013 Accepted on: 04/03/2013 Available online: 30/03/2013 The present study aims to investigate the antidiabetic activity of roots of Cayratia trifolia (L.) Domin in alloxan induced diabetic rats. Phytochemical studies showed the presence of steroids, flavonoids and alkaloids in petroleum ether, ethyl acetate and ethanol extracts, respe...