Depression affects more than 300 million people worldwide, represents one of the leading causes of disability worldwide. Treatment is based on the use of tricyclic antidepressant, selective serotonin reuptake inhibitors, between others; that although are clinically effective has a delayed onset activity and produce important side effects. Medicinal plants are presented as a source of study in t...

Depression affects more than 300 million people worldwide, represents one of the leading causes of disability worldwide. Treatment is based on the use of tricyclic antidepressant, selective serotonin reuptake inhibitors, between others; that although are clinically effective has a delayed onset activity and produce important side effects. Medicinal plants are presented as a source of study in t...

The effect of 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline psychopharmacological activity on the duration sleep, which was induced with sodium etaminal, catalepsy, help haloperidol, an anti-anxiety, antidepressant activity, studied. and obtained necessary conclusions.

OBJECTIVES The effect of retirement on mental health is not well understood. We examined the prevalence of hospital treatment for depression and purchase of antidepressant medication before, during and after retirement in a Danish population sample. We hypothesised that retirement was followed by reduced prevalence of hospital treatment for depression and antidepressant purchase. METHODS Part...

Despite limited understanding of the pathophysiology of depression and the underlying mechanisms mediating antidepressant effects, there are several efficient treatments. The anhedonia symptoms of depression are characterized by decreased motivation and drive and imply possible malfunctioning of the mesolimbic dopamine system, whereas cognitive deficits might reflect decreased plasticity in hip...

introduction & objective: patients with major depressive are difficult to treat, and the relative efficacy of medications and cognitive therapy in the treatment of depression is still a matter of deabath. the purpose of this study was to compare the efficacies of antidepressant medication, cognitive therapy and combination of cognitive therapy and antidepressant medication. materials & methods:...

The antidepressant- and anxiolytic-like effects of magnesium, an N-methyl-d-aspartate (NMDA) glutamate receptor inhibitor, were studied in mice using the forced swim test and elevated plus-maze test, respectively. The doses of 20 and 30 mg Mg/kg, reduced immobility time in the forced swim test exerting antidepressant-like activity. In the elevated plus-maze test, magnesium at the same doses pro...

Zinc is a trace element, which is an important modulator of mammalian nervous and immune systems. Its deficiency is related to human depression. Our recent data indicate involvement of zinc in the mechanism of antidepressant treatment. Moreover, zinc exhibits antidepressant-like effects in animal models of depression in rodents. Since zinc also enhances antidepressant effect in laboratory anima...

Behavioral studies show that modulation of the glutamatergic system might be an efficient way to achieve antidepressant activity. Among the group III metabotropic glutamate (mGlu) receptors, the mGlu7 receptor subtype seems to be the most promising target for potential antidepressants. It has been shown that a selective, allosteric mGlu7 receptor agonist, N,N'-bis (diphenylmethyl)-1,2-ethanedia...

Alpha (α)-asarone is one of the main psychoactive compounds, present in Acorus species. Evidence suggests that the α-asarone possess an antidepressant-like activity in mice. However, the exact dose-dependent effect of α-asarone and mechanism(s) involved in the antidepressant-like activity are not clear. The present study aimed to investigate the dose-dependent effect of α-asarone and the underl...