Optimal timing for restarting anticoagulant therapy after intracranial bleeding is a critical issue. The purpose of this systematic review is to summarize published studies on the management of oral anticoagulant therapy after intracranial bleeding secondary to the use of vitamin K antagonists in patients with a mechanical heart valve. A computer-assisted search of the MEDLINE and EMBASE electr...

OBJECTIVE To investigate the costs and effects of long-term oral anticoagulant treatment after myocardial infarction. DESIGN Cost-effectiveness analysis, based on a randomized, double-blind, placebo-controlled trial. SETTING Sixty Dutch hospitals. PATIENTS A total of 3404 hospital survivors of acute myocardial infarction randomized within a median period of 4 days after discharge to eithe...