The increasing incidence and prevalence of antibiotic resistance in bacteria threatens the "antibiotic miracle." Conventional antimicrobial drug development has failed to replace the armamentarium needed to combat this problem, and novel solutions are urgently required. Here we review both natural and synthetic RNA silencing and its potential to provide new antibacterials through improved targe...

Minocycline is an antibiotic used increasingly in a variety of situations including MRSA infections and also known for its anti-inflammatory properties. Its side effects are usually benign and well known. We report a first of its kind case of minocycline-associated acute pancreatitis in a patient in whom all other common causes of pancreatitis were ruled out. The aim is to raise awareness about...

Recently Sumiki and his co-workers (1955) isolated a new antibiotic, named homomycin, from the culture filtrate of a streptomyces obtained from the soil of Inada-Noborito, Kanagawa Prefecture, Japan. This strain of streptomyces was considered as a new species according to their taxonomic study, and designated as Streptomyces noboritoensis. The method of preparation of purified material of homom...

Orbeseal consists of bismuth subnitrate formulated into an inert viscous malleable paste that does not have any antibiotic or antimicrobial properties. It is delivered in a tube and is infused into the teat end after drying off in a manner similar to infusing a dry cow antibiotic. After infusion it fills the fissures and folds of the teat canal thereby creating a seal preventing the entrance of...

The antimicrobial properties and the elution characteristics of gentamicin-vancomycin-loaded hip spacers were studied in vivo and in vitro. Vancomycin elution was greater than gentamicin elution. The antibiotic concentrations in vivo were less than those in vitro. Not dependent on implantation duration, growth inhibition by spacers in vitro was observed for 2 weeks. The reason for protracted wo...

In the course of our search for new antibiotics produced by Streptomyces sp., a water-soluble antibiotic, effective against gram-negative bacteria, was obtained from the nitrate of a culture broth of Streptomyces No. 5879 isolated from a soil sample collected in Aizu area (Fukushima prefecture). Antibiotic No. 5879 appears to be a novel one from its physico-chemical and biological properties, a...

Syringomycin, a wide-spectrum antibiotic produced by strains of Pseudomonas syringae which cause bacterial canker of peach, was able to bind to salmon sperm and calf thymus deoxyribonucleic acid but not to calf thymus histone; it also inhibited ribonucleic acid polymerase activity. These abilities to bind to deoxyribonucleic acid and to inhibit ribonucleic acid polymerase were inactivated when ...

UNLABELLED Bacterial conjugation constitutes a major horizontal gene transfer mechanism for the dissemination of antibiotic resistance genes among human pathogens. Antibiotic resistance spread could be halted or diminished by molecules that interfere with the conjugation process. In this work, synthetic 2-alkynoic fatty acids were identified as a novel class of conjugation inhibitors. Their che...

aim: the increasing prevalence of antibiotic-resistant bacteria is a major health-care problem worldwide. who recommends did (daily defined dose/ 100 inhabitant /day) as a standard tool for measurement of antibiotic consumption. since there was not any information regarding the antibiotics usage pattern in the north of iran, the aim of this study was determine this in our centre.method: this cr...

Setamycin which has been isolated by Omura et al.,1*^ is a macrolide antibiotic possessing activities against trichomonads, some fungi and Gram-positive bacteria. The morphological and physiological properties of its producing organism led to a new genus designated as Kitasatosporia setae of the order ActinomycetalesP Recently, many unusual 16-memBered macrolides4) such as hygrolidins,5»6) L681...