Abstract Non-small cell lung cancer (NSCLC) is the leading cause of malignancy-related deaths worldwide. We wished to overcome a current major limitation PDX modeling, by providing autologous human T cells suitable for immunotherapy responses, but notably, without graft versus host disease (GVHD). have developed PDXs from NSCLC implanting surgically resected patient tumors subcutaneously in NOD...

introduction as a tumor grows, the demand for oxygen and nutrients increases and it grows further if acquires the ability to induce angiogenesis. in this study, we aimed to present a two-dimensional continuous mathematical model for avascular tumor growth, coupled with a discrete model of angiogenesis. materials and methods in the avascular growth model, tumor is considered as a single mass, wh...

Abstract CTLA-4 blockade in combination with an agonist OX40-specific monoclonal antibody synergizes to augment antitumor immunity through enhanced T-cell effector function, leading increased survival preclinical cancer models. We have shown previously that anti-OX40/anti–CTLA-4 therapy synergistically enhances the expression of Eomesodermin (Eomes) CD8+ T cells. Eomes is a critical transcripti...

objective(s):tumor-associated antigen (taa) subunit-based vaccines constitute promising tools for anticancer immunotherapy. however, a major limitation in the development of such vaccines is the poor immunogenicity of peptides when used alone.the aim of this study was to develop an efficient vaccine delivery system and adjuvant to enhance anti-tumor activity of a synthetic her2/neu derived pept...