BACKGROUND Epilepsy is one of the major brain disorders worldwide. Breakthrough seizures carry a heavy burden of epilepsy, with increased morbidity and risk of premature mortality. Several factors have been suggested to precipitate break through seizures but these have not been studied in our setting. The study sought to determine the prevalence of breakthrough seizures, as well as precipitatin...

PEA attenuates chemotherapy-induced neuropathies by attenuating endoneueral edema in myelinated nerve fibers [2]. Similarly, PEA improves distal motor latency in individuals with carpal tunnel syndrome [3]. Similar benefits have been noticed in pudendal neuralgias [4]. PEA also exerts beneficial effects in patients with multiple sclerosis by ameliorating neuropathic pain [5]. PEA also increases...

In the brain, seizures lead to release of large amounts of polyunsaturated fatty acids including arachidonic acid (ARA). ARA is a substrate for three major enzymatic routes of metabolism by cyclooxygenase, lipoxygenase and cytochrome P450 enzymes. These enzymes convert ARA to potent lipid mediators including prostanoids, leukotrienes and epoxyeicosatrienoic acids (EETs). The prostanoids and leu...

Background: Seizures in childhood absence epilepsy (CAE) are typically easily controlled with anti-seizure medications (ASMs). Factors predictive of treatment resistance remain unclear. Our objectives were to assess prevalence neuropsychiatric problems and factors influencing a cohort CAE at single centre. Methods: We retrospectively reviewed patients diagnosed between January 1999 December 201...

Hydantoin derivatives are commonly used anticonvulsants. In general, they effective for partial-onset seizures and tonic-clonic seizures, but not absence seizures. Phenytoin is the most important drug in this group, other drugs, ethotoin, mephenytoin, also to treat epilepsy. Prodrugs such as have been created. some cases of trigeminal neuralgia related neuralgia. arrhythmias. Hydantoins or glyc...

Objective(s): Neurodegenerative diseases have been associated with glutamatergic dysfunction. Berberine, an isoquinoline alkaloid broadly present in different medicinal herbs, has been reported to have neuroprotective effect. In the present study, the effects of berberine against glutamate-induced oxidative damage and apoptosis were investigated. Materials and Methods: The cultured PC12 and N2a...

Commentary Synaptic inhibition critically controls neural circuit excitabil-ity in the brain; reduced functional inhibition due to loss of GABAergic neurons, dysregulation of surviving GABA cells, and altered GABA receptor responses accompanies development of spontaneous seizures in animal models of acquired temporal lobe epilepsy (TLE). In many TLE patients, altered inhibitory control is also ...

An important role for oxidative stress both as a consequence and as a cause of epileptic seizures has been suggested. Since Achillea wilhelmsii (A. wilhelmsii) has been considered to have the antioxidant effects as well as central nervous system depressant properties, the anti-seizure effects of the plant extract in addition to its effects on brain tissues oxidative damage were investigated in ...

objective 1-3% of the population suffer from epilepsy. up to 30% of them develop refractory epilepsy and their seizures occur more than once per month despite receiving at least 2 first line antiepileptic drugs. in  this group, more efficacious antiepileptics are needed. this study was undertaken to evaluate the efficacy and safety of oxcarbazepine as an adjunction therapy in children with refr...

BACKGROUND Explosive synaptogenesis and synaptic pruning occur in the hippocampus during the first two weeks of postnatal life, coincident with a heightened susceptibility to seizures in rodents. To determine the temporal correlation between microglial development and age-dependent susceptibility and response to seizures, we quantified developmental changes in basal microglia levels and seizure...