introduction: intravenous drug users as a serious health problem in communities have economical and social effects as well as health and hygienic complications. viral infections may be transmitted through drug injection by shared syringes among users. the aim of this study has been to determine the relative frequency of hbv, hcv and hiv infection’s markers as epidemiological data in ahvaz. mate...

Background: HSV-2, one of the most common HIV-1 copathogens, establishes a synergistic interaction with HIV-1. Several clinical trials have shown that the anti herpetic drug acyclovir decreases HIV-1 viral load and delays HIV-1 disease progression. Similarly, CAPRISA004 reported that a vaginal gel containing 1% of the anti-HIV-1 drug tenofovir unexpectedly decreases the risk of HSV-2 acquisitio...

The conjugates of some dicarboxylic acid hemiesters of triterpenes which show potent inhibition against human immunodeficiency virus type 1 protease (HIV-1 PR) with a reverse transcriptase inhibitor azidothymidine (AZT) or anti-HIV alkaloid FK 3000 were prepared, and their inhibitory activities were investigated against HIV-induced cytopathic effects (CPE) and HIV-1 PR. Most of the triterpene-A...

In HIV-infected patients, increased levels of IL-10, mainly produced by virally infected monocytes, were reported to be associated with impaired cell-mediated immune responses. In this study, we investigated how HIV-1 induces IL-10 production in human monocytes. We found that CD14(+) monocytes infected by either HIV-1(213) (X4) or HIV-1(BaL) (R5) produced IL-10, IL-6, tumor necrosis factor-alph...

Objective: To investigate the carriage of HBs antigen (Ag) and hepatitis C virus in people with human immunodeficiency (HIV) at Grand-Yoff General Hospital.
 Materials Methods: Sera from patients living HIV monitored Hospital have benefited research for Ag, HBe anti-H[8] Be antibodies on these co-infected patients, a test was also carried out.
 Results: This study included 147 HIV-inf...

Predictive quantitative structure–activity relationship was performed on the novel 4-oxo-1,4-dihydroquinoline and 4-oxo-4H-pyrido[1,2-a]pyrimidine derivatives to explore relationship between the structure of synthesized compounds and their anti-HIV-1 activities. In this way, the suitable set of the molecular descriptors was calculated and the important descriptors using the variable selections ...

Introduction HIV infection becomes the present problematic infectious disease worldwide. The pathogenic HIV virus will destroy immune system of the patients and result in several clinical problems. Anti-HIV medication is the standard treatment for the HIV infected patient. An important concern of anti-HIV drugs use is the possible adverse effects (1). The kidney problems due to anti-HIV is wide...

1. Abstract 2. Introduction 3. Phenotype of hematopoietic stem cells 4. Sources of hematopoietic stem cells 5. Anti-HIV genes 6. Gene transfer into hematopoietic stem cells 6.1. Retroviral vectors 6.2. Lentiviral vectors 7. Gene expression 8. Clinical trials 8.1. Transfer of an anti-HIV-1 ribozyme into CD34 PBSC from HIV-1-positive adults 8.2. Transfer of an RRE decoy gene into CD34 cells from ...

The anti-HIV pharmaceutical efavirenz is highly dynamic in its crystalline state, and we show that these dynamics can be tamed through the introduction of a coformer.

Objectives: Prevention of hepatitis B virus (HBV) infection is necessary for patients with human immunodeficiency (HIV), since co-infection associated increased in mortality. The aim this study was to investigate response double-dose HBV vaccine HIV. Methods: A total 149 HIV were retrospectively evaluated. Sixty-eight who seronegative and administered included the study. According anti HBs leve...